Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TACC3 contributors: mct/pgu - updated : 25-06-2013
HGNC name transforming, acidic coiled-coil containing protein 3
HGNC id 11524
Location 4p16.3      Physical location : 1.723.265 - 1.746.895
Synonym symbol(s) ERIC1, MGC117382, MGC133242
DNA
TYPE functioning gene
STRUCTURE 23.63 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PCDH18 4q31.2-q32 protocadherin 18 LOC389255 4 similar to RSTI689 LOC152687 4p16.3 hypothetical protein LOC152687 AMBN 4q21 ameloblastin, enamel matrix protein FLJ90036 4p16.3 hypothetical protein FLJ90036 LOC391611 4 similar to Zinc finger protein 208 ZNF141 4p16.3 zinc finger protein 141 (clone pHZ-44) FLJ14297 4p16.3 hypothetical protein FLJ14297 FLJ20265 4p16.3 hypothetical protein FLJ20265 PDE6B 4p16.3 phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant) ATP5I 4p16.3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit e MYL5 4p16.3 myosin, light polypeptide 5, regulatory FLJ22269 4p16.3 hypothetical protein FLJ22269 RNF3 4p16.3 ring finger protein 3 CPLX1 4p16.3 complexin 1 GAK 4p16 cyclin G associated kinase MGC4618 4p16.3 hypothetical protein MGC4618 DGKQ 4p16.3 diacylglycerol kinase, theta 110kDa SLC26A1 4p16.3 solute carrier family 26 (sulfate transporter), member 1 IDUA 4p16.3 iduronidase, alpha-L- FGFRL1 4p16 fibroblast growth factor receptor-like 1 LOC285498 4p16.3 hypothetical protein LOC285498 LOC132969 4p16.3 similar to hornerin SPON2 4p16.3 spondin 2, extracellular matrix protein CTBP1 4p16 C-terminal binding protein 1 MGC21675 4p16.3 hypothetical protein MGC21675 MAEA 4p16.3 macrophage erythroblast attacher KIAA1530 4p16.3 KIAA1530 protein FLJ34443 4p16.3 hypothetical protein FLJ34443 HSPX153 4p16.3 HPX-153 homeobox LOC345375 4p16.3 similar to CG32656-PA LOC152877 4p16.3 similar to RIKEN cDNA 5430419M09 SLBP 4p16 stem-loop (histone) binding protein LOC92305 4p16.3 hypothetical protein BC009331 TACC3 4p16.3 transforming, acidic coiled-coil containing protein 3 FGFR3 4p16.3 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) LETM1 4p16.3 leucine zipper-EF-hand containing transmembrane protein 1 WHSC1 4p16.3 Wolf-Hirschhorn syndrome candidate 1 WHSC2 4p16.3 Wolf-Hirschhorn syndrome candidate 2 LOC389195 4 hypothetical gene supported by BC038466; BC047038 FLJ37478 4p16.3 hypothetical protein FLJ37478 POLN 4p16.3 polymerase (DNA directed) nu MGC4701 4p16.3 hypothetical protein MGC4701 MXD4 4p16.3 MAX dimerization protein 4 KIAA1643 4p16.3 KIAA1643 protein LOC339985 4p16.3 hypothetical gene supported by BC010180 RNF4 4p16.3 ring finger protein 4 C4orf8 4p16.3 chromosome 4 open reading frame 8 TNIP2 4p16.3 TNFAIP3 interacting protein 2 LOC389196 4 LOC389196 SH3BP2 4p16.3 SH3-domain binding protein 2 ADD1 4p16.3 adducin 1 (alpha) TETRAN 4p16.3 tetracycline transporter-like protein C4orf9 4p16.3 chromosome 4 open reading frame 9 GPRK2L 4p16.3 G protein-coupled receptor kinase 2-like (Drosophila) HD 4p16.3 huntingtin (Huntington disease) LOC345222 4p16.3 hypothetical gene supported by BC043530 RGS12 4p16.3 regulator of G-protein signalling 12 HGFAC 4p16.3 HGF activator FLJ33718 4p16.3 hypothetical protein FLJ33718
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2788 - 838 - 2006 16964243
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   lowly
 thymus   highly
Digestiveintestine   lowly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage hematopoietic cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • myosin tail
  • tyrosine phosphorylation site
  • C terminal coiled-coil region, 200- AA coiled coil motif, TACC domain, consisting of two functionally distinct subdomains, CC1 aa 414-530) and CC2 (aa 530-630)
  • HOMOLOGY
    interspecies homolog to murine Tacc3
    Homologene
    FAMILY
  • TACC family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nuclear envelope
    text
  • perinuclear vesicles of dermal microvascular endothelial cells
  • subcellular localization at the mitotic spindle apparatus (
  • basic FUNCTION
  • involved in cell growth and differentiation, role in terminal erythropoiesis
  • playing an essential role in hematopoietic stem cell function and genetically interfacing with TP53 -regulated apoptosis
  • involved in spindle assembly and cellular survival
  • may play a role in the microtubule-dependent coupling of the nucleus and the centrosome
  • may contribute to cancer
  • involved in the process that regulate centrosome-mediated interkinetic nuclear migration of neural progenitors
  • contributes to the regulation of gene transcription
  • negative regulator of the Notch signaling pathway
  • a TACC3/CKAP5/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging
  • non-motor microtubule-associated protein (MAP) that is important for mitotic spindle stability and organization
  • essential for mitotic spindle dynamics and centrosome integrity during mitosis
  • is a driver of tumorigenesis as well as an inducer of oncogenic EMT and highlight its overexpression as a potential therapeutic target for preventing EMT-associated tumor progression and invasion
  • crucial for proper mitotic spindle assembly and dynamics to prevent faulty cell division and aneuploidy
  • essential for proper kinetochore capture and kinetochore fiber formation
  • critical TACC3-dependent acentrosomal microtubule nucleation and sorting process to regulate kinetochore–microtubule connections
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    protein
  • ARNT
  • ARNT2
  • interacting with GCN5L2 and PCAF
  • centrosomal protein that interacts with CKAP5
  • specifically interacts with the NOTCH4/CDC10/Ankyrin repeats
  • binding partner for NOTCH4 that acts as a negative regulator of Notch signaling, and also binds to the other members of the Notch receptor family
  • performs its centrosome clustering activity in a focal adhesion-independent, but centrosome-dependent, manner through the microtubule regulating proteins TACC3 and CKAP5
  • CLTC binds specifically to phosphorylated TACC3 and recruits it to spindle poles for proper spindle assembly and chromosome alignment
  • at microtubules contains clathrin in addition to its previously identified binding partner CKAP5
  • adaptor that recruits CKAP5 and clathrin to mitotic microtubules, in an AURKA-regulated manner
  • DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
  • TACC3 is an AURKA substrate essential in central spindle formation
  • is also a target of the RAN GTPase system, and it may coordinate with RAN to regulate acentrosomal microtubules for kinetochore capture
  • C-terminal TACC domain of TACC3 and a C-terminal fragment adjacent to the TOG domains of CKAP5 mediate the interaction between TACC and CKAP5, interaction required for spindle assembly and microtubule dynamics during mitotic cell division
  • cell & other
  • microtubules
  • REGULATION
    activated by EPO in erythroid progenitors
    Other phosphorylated by AURKA, essential for the proper localization to centrosomes and proximal mitotic spindles
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in various cancer cell lines
    tumoral     --over  
    in multiple myeloma with t(4;14)(p16;q32)
    tumoral     --low  
    down-regulated by paclitaxel treatment in cervical cancer cells, overexpression of TACC3 may be associated with the mechanisms of chemoresistance, tumor progression, cell proliferation and metastasis
    tumoral     --low  
    reduced expression in follicular, papillary and anaplastic thyroid carcinomas
    tumoral fusion      
    of FGFR1 or FGFR3, to the transforming acidic coiled-coil (TACC) coding domains of TACC1 or TACC3, respectively in glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential therapeutic target in cancer cells
    cancerhemopathy 
    is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target
    ANIMAL & CELL MODELS