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FLASH GENE
Symbol TACC2 contributors: mct/npt - updated : 13-03-2009
HGNC name transforming, acidic coiled-coil containing protein 2
HGNC id 11523
Location 10q26.13      Physical location : 123.748.688 - 124.014.055
Synonym name
  • anti zuai-1
  • endothelial TACC related
  • Synonym symbol(s) AZU-1, ECTACC
    DNA
    TYPE functioning gene
    STRUCTURE 265.40 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4144 120 1094 brain, prostate, thyroid,trachea Lauffart, Dou (2004)
    23 - 9706 310 2948 bladder, placenta, skeletal and heart muscle Lauffart, Dou (2004)
    17 - 3825 108.6 996 - Dou (2004)
    17 - 3916 112 1026 - Dou (2004)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratoryrespiratory tracttrachea   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal serine and proline rich domain with a predicted immunoglobulin-like fold
  • C terminal coiled-coil region
  • HOMOLOGY
    interspecies homolog to murine Tacc2
    Homologene
    FAMILY
  • TACC family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text in centrosome during cell cycles
    basic FUNCTION
  • playing a role in organizing centrosomal microtubules
  • tumor progression marker
  • centrosomal TACC2 is required for mitotic spindle maintenance (Dou 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • microtubules
  • GAS41, SWI/SNF chromatin remodeling complex (SMARCB1)
  • interaction between TTK and TACC2 established provides new avenue to study centrosome and spindle dynamics underlying cell divisional control (Dou 2004)
  • cell & other
    REGULATION
    activated by SMYD2 gain of function (up-regulation of TACC2 by SMYD2 occurred as a result of SMYD2 binding to the TACC2 promoter where it methylates H3K4) (Abu-Farha 2008)
    Other phosphorylated in mitosis by TTK signaling pathway (Dou 2004)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS