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FLASH GENE
Symbol TACC2 contributors: mct/npt - updated : 13-03-2009
HGNC name transforming, acidic coiled-coil containing protein 2
HGNC id 11523
Location 10q26.13      Physical location : 123.748.688 - 124.014.055
Synonym name
  • anti zuai-1
  • endothelial TACC related
  • Synonym symbol(s) AZU-1, ECTACC
    DNA
    TYPE functioning gene
    STRUCTURE 265.40 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC196051 10q26.13 hypothetical protein LOC196051 WDR11 10q26 WD repeat domain 11 FGFR2 10q26 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) ATE1 10q26.13 arginyltransferase 1 FLJ20003 10q26.13 hypothetical protein FLJ20003 TACC2 10q26 transforming, acidic coiled-coil containing protein 2 FLJ25359 10q26.13 hypothetical protein FLJ25359 PLEKHA1 10q26.3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 LOC387715 10 LOC387715 PRSS11 10q25.3-q26.2 protease, serine, 11 (IGF binding) LOC253436 10q26.13 hypothetical LOC253436 LOC390008 10 similar to hensin CUZD1 10q26.13 CUB and zona pellucida-like domains 1 MGC45962 10q26.13 hypothetical protein MGC45962 LOC118670 10q26.13 similar to hypothetical protein MGC45962 FLJ13490 10q26.13 hypothetical protein FLJ13490 MGC35392 10q26.13 hypothetical protein MGC35392 PEGASUS 10q26 zinc finger protein, subfamily 1A, 5 (Pegasus) ACADSB 10q25-q26 acyl-Coenzyme A dehydrogenase, short/branched chain LOC340784 10q26.13 similar to NK-type homeobox LOC387716 10 similar to Hmx2 protein LOC387717 10 LOC387717 BUB3 10q26 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) LOC390009 10 similar to 40S ribosomal protein S26 GPR26 10q26.2-q26.3 G protein-coupled receptor 26 DKFZp761H2121 10q26.13 hypothetical protein DKFZp761H2121 LOC119587 10q26.13 hypothetical protein LOC119587 GALNAC4S-6ST 10q26 hypothetical protein LOC119587
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4144 120 1094 brain, prostate, thyroid,trachea Lauffart, Dou (2004)
    23 - 9706 310 2948 bladder, placenta, skeletal and heart muscle Lauffart, Dou (2004)
    17 - 3825 108.6 996 - Dou (2004)
    17 - 3916 112 1026 - Dou (2004)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratoryrespiratory tracttrachea   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal serine and proline rich domain with a predicted immunoglobulin-like fold
  • C terminal coiled-coil region
  • HOMOLOGY
    interspecies homolog to murine Tacc2
    Homologene
    FAMILY
  • TACC family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text in centrosome during cell cycles
    basic FUNCTION
  • playing a role in organizing centrosomal microtubules
  • tumor progression marker
  • centrosomal TACC2 is required for mitotic spindle maintenance (Dou 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • microtubules
  • GAS41, SWI/SNF chromatin remodeling complex (SMARCB1)
  • interaction between TTK and TACC2 established provides new avenue to study centrosome and spindle dynamics underlying cell divisional control (Dou 2004)
  • cell & other
    REGULATION
    activated by SMYD2 gain of function (up-regulation of TACC2 by SMYD2 occurred as a result of SMYD2 binding to the TACC2 promoter where it methylates H3K4) (Abu-Farha 2008)
    Other phosphorylated in mitosis by TTK signaling pathway (Dou 2004)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS