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FLASH GENE
Symbol TAC4 contributors: - updated : 27-10-2004
HGNC name tachykinin 4 (hemokinin)
HGNC id 16641
Location 17q21.33      Physical location : 47.915.670 - 47.925.379
Synonym symbol(s) HK-1, Pptc, PPT-C
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   lowly
 stomach   lowly
Endocrineadrenal gland    
 thyroid   highly
Nervousbraindiencephalonhypothalamus specific
Reproductivefemale systemplacenta  lowly
 male systemprostate  lowly
 male systemtestis  lowly
Respiratorylung   lowly
Skin/Tegumentskin   highly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text liver, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two potential monobasic cleavage sites
isoforms Precursor mature peptide of 11aa
HOMOLOGY
interspecies homolog to murine PPT-C
Homologene
FAMILY preprotachykinin family
CATEGORY signaling neurotransmitter
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • may be implicated in regulation of B-cell development
  • cardiovascular activity
  • ligand activity of the NK1 receptor, may play an important role in mediating some of NK1 receptor physiological roles
  • may be involved in controlling blood flow during pregnancy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of the NK1 receptor
  • having affinity for NK2 and NK3 receptors too
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS