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FLASH GENE
Symbol TAC4 contributors: - updated : 27-10-2004
HGNC name tachykinin 4 (hemokinin)
HGNC id 16641
Location 17q21.33      Physical location : 47.915.670 - 47.925.379
Synonym symbol(s) HK-1, Pptc, PPT-C
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ13855 17q21.33 hypothetical protein FLJ13855 EAP30 17q21.33 EAP30 subunit of ELL complex GIP 17q21.31 gastric inhibitory polypeptide IMP-1 17q21.33 IGF-II mRNA-binding protein 1 GALGT2 17q21.3 beta 1,4 N-acetylgalactosaminyltransferase GNGT2 17q21.3 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 NESH 17q21.3 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 PHOSPHO1 17q21.32 phosphatase, orphan 1 LOC124871 17q21.33 hypothetical gene LOC124871 KIAA0924 17q21.32 hypothetical gene LOC124871 PHB 17q21.3 prohibitin LOC388400 17 similar to Eukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) NGFR 17q21.31 nerve growth factor receptor (TNFR superfamily, member 16) NXPH3 17q21.31 neurexophilin 3 SPOP 17q22 speckle-type POZ protein SLC35B1 17q21.3-q22 solute carrier family 35, member B1 LOC81558 17q21.33 C/EBP-induced protein MYST2 17q21.32 MYST histone acetyltransferase 2 TAC4 17 tachykinin 4 (hemokinin) LOC124865 17q21.33 similar to ribosomal protein P0-like protein; 60S acidic ribosomal protein PO; ribosomal protein, large, P0-like DLX4 17q21-q22 distal-less homeobox 4 DLX3 17q21.3-q22 distal-less homeo box 3 ITGA3 17q22-q23 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) PDK2 17q21.3 pyruvate dehydrogenase kinase, isoenzyme 2 LOC201191 17q21.33 hypothetical protein LOC201191 PPP1R9B 17q21-q22 protein phosphatase 1, regulatory subunit 9B, spinophilin SGCA 17q21 sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) HILS1 17q21.33 spermatid-specific linker histone H1-like protein COL1A1 17q21.31-q22.15 collagen, type I, alpha 1 FLJ33318 17q21.33 hypothetical protein FLJ33318 XYLT2 17q21.3-17q22 xylosyltransferase II MRPL27 17q21.3-q22 mitochondrial ribosomal protein L27 FLJ31364 PRO1855 17q21.33 hypothetical protein PRO1855 FLJ20920 17q21.33 hypothetical protein FLJ20920 MRPS21P9 17q21 mitochondrial ribosomal protein S21 pseudogene 9 CHAD 17q21.33 chondroadherin FLJ11164 17q21.33 hypothetical protein FLJ11164 DKFZp434N1415 17q21.33 Mycbp-associated protein EPN3 17q24.1 epsin 3 FLJ21347 17q21.33 hypothetical protein FLJ21347 LOC253962 17q21.33 hypothetical protein LOC253962 CACNA1G 17q22 calcium channel, voltage-dependent, alpha 1G subunit
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   lowly
 stomach   lowly
Endocrineadrenal gland    
 thyroid   highly
Nervousbraindiencephalonhypothalamus specific
Reproductivefemale systemplacenta  lowly
 male systemprostate  lowly
 male systemtestis  lowly
Respiratorylung   lowly
Skin/Tegumentskin   highly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text liver, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two potential monobasic cleavage sites
isoforms Precursor mature peptide of 11aa
HOMOLOGY
interspecies homolog to murine PPT-C
Homologene
FAMILY preprotachykinin family
CATEGORY signaling neurotransmitter
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • may be implicated in regulation of B-cell development
  • cardiovascular activity
  • ligand activity of the NK1 receptor, may play an important role in mediating some of NK1 receptor physiological roles
  • may be involved in controlling blood flow during pregnancy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of the NK1 receptor
  • having affinity for NK2 and NK3 receptors too
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS