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FLASH GENE

Symbol

TAC3

contributors: mct/npt - updated : 06-06-2015

HGNC name	tachykinin 3
HGNC id	11521

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	HHGT hypogonadotropic hypogonadism, familial
Location	12q13.3      Physical location : 57.403.781 - 57.410.344
Synonym name	tachykinin 3 (neuromedin K, neurokinin beta)
	gamma tachykinin 3
	neurokinin B-like protein
	preprotachykinin B
Synonym symbol(s)	NKA, NKNB , ZNEUROK1, TKNK, NKB, PRO1155

DNA

TYPE	functioning gene
STRUCTURE	6.54 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 7 - 832 isoform 1 13.31 121 - Topaloglu (2009)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus   predominantly Homo sapiens Reproductive female system ovary       Homo sapiens   female system oviduct       Homo sapiens   female system uterus       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, syncytiotrophoblast

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

tachykinin family

CATEGORY

signaling hormone

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	potent vasodilator and secretagogue, and contracting (directly or indirectly) many smooth muscles
	paracrine modulator of tone in the fetal placental circulation (Brownbill 2004)
	critical central regulator of gonadal function (Topaloglu 2009)
	TAC3/TACR3 have been implicated in the neuroendocrine control of GNRH1 release
	TAC3 and its preferred tachykinin receptor 3 (TACR3) are prominently detected in the central nervous system, playing significant roles in physiological development and specifically in the human reproductive system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HHGT

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in women with pre-eclampsia during the third trimester of pregnancy (increased placental expression of TAC3 is part of the mechanism leading to the increased circulating levels of TAC3 in pre-eclampsia)(Page 2006) constitutional     --over   of TAC3 and UTS2 in the plasma of pre-eclamptic women

Susceptibility

Variant & Polymorphism

Candidate gene	TAC3/TACR3 system may provide a new avenue for the pharmacological manipulation of human fertility and the treatment of sex steroid–related diseases, such as cancers of the breast and prostate (Topaloglu 2009)
Marker
Therapy target

ANIMAL & CELL MODELS