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FLASH GENE
Symbol TAC1 contributors: mct/npt/pgu - updated : 22-10-2013
HGNC name tachykinin, precursor 1
HGNC id 11517
Location 7q21.3      Physical location : 97.361.270 - 97.369.782
Synonym name
  • tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
  • neuromedin L
  • neurokinin 1
  • neurokinin 2
  • neurokinin A
  • neuropeptide K
  • substance P
  • Synonym symbol(s) HSP, TAC2, NK2, TKN1, Hs.2563, NKNA, NKA, NKP, PPT, SP
    DNA
    TYPE functioning gene
    STRUCTURE 8.51 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SLC25A13 7q21.3 solute carrier family 25, member 13 (citrin) HCP18 7q21.3 cytochrome c, somatic pseudogene SHFM1 LOC392075 7 similar to Ser/Thr protein kinase PAR-1Balpha DLX6 7q21.3 distal-less homeo box 6 DLX5 7q21.3 distal-less homeo box 5 ACN9 7q22.1 ACN9 homolog (S. cerevisiae) LOC392076 7 similar to Rpl7a protein TAC1 7q21.3-q22.1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) ASNS 7q21.3 asparagine synthetase LOC389534 7 LOC389534 LOC389535 7 similar to hypothetical protein LOC286031 LOC389536 7 similar to seven transmembrane helix receptor LOC389537 7 similar to olfactory receptor GA_x6K02T2PVTD-14054886-14053957 LOC389538 7 similar to hypothetical protein MGC56855 OCM 7p13-p11 oncomodulin KPI2 7q22.1 oncomodulin MIST1 7q22.1 class II bHLH protein MIST1 DKFZP434B0335 7q22.1 DKFZP434B0335 protein BRI3 7q22.1 brain protein I3 LOC55971 7q22.1 insulin receptor tyrosine kinase substrate NPTX2 7q21.3-q22.1 neuronal pentraxin II DKFZp761L1417 7q22.1 hypothetical protein DKFZp761L1417 TRRAP 7q21.3-q22.1 transformation/transcription domain-associated protein SMURF1 7q21.1-q31.1 transformation/transcription domain-associated protein LOC389539 7 similar to importin alpha 1b ARPC1A 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1A, 41kDa ARPC1B 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1B, 41kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1188 - 129 - 2009 19046942
    also called TAC1-beta
    6 splicing 1134 - 111 - 2009 19046942
    also called TAC1-alpha
    6 splicing 1143 - 114 - 2009 19046942
    also called TAC1-gamma
    5 splicing 1003 - 96 - 2009 19046942
    also called TAC1-delta
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Nervousbrain    
     nerve    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Tac1
    Homologene
    FAMILY
  • tachykinin family
  • CATEGORY signaling neurotransmitter , receptor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues,
  • and contract (directly or indirectly) many smooth muscles
  • possesses antiapoptotic effects in the colonic mucosa by activating AKT, which prevents apoptosis and mediates tissue recovery during colitis
  • centrally involved in gastric secretion, motility, mucosal immunity, and cell proliferation
  • playing a role in the regulation of platelet function
  • catabolized by degradative enzymes in tears to maintain the ocular surface by exerting the trophic effects of SP while avoiding undesirable effects
  • multipotent neuropeptide that affects the proliferation, activation and motility of keratinocytes and fibroblasts
  • TAC1/TACR1 system, leads to the activation of nuclear factor-kappa B (NFKB) and proinflammatory cytokines
  • role for TAC1/TACR1 interactions in adipose tissue responses, specifically as they relate to obesity-associated pathologies such as glucose intolerance and insulin resistance
  • upregulated monocyte tissue factor (TF), the major coagulation cascade stimulator, in a concentration and time dependent manner
  • beyond its neuroendocrine and inflammatory effects, could also be involved in targeting adipose tissue and influencing insulin resistance
  • promotes neurite outgrowth and the migration of pancreatic cancer cell cluster to the dorsal root ganglions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interact with P-glycoprotein as endogenous substrates for P-glycoprotein-mediated transport
  • ligand of TACR1
  • TAC1/TACR1 system is a major class 1, rhodopsin-like GPCR ligand-receptor interaction
  • TAC1/TACR1 interaction upregulates monocyte tissue factor
  • cell & other
    REGULATION
    Other TAC1 in pulmonary and synovial cells is degraded by CD10
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    aberrant silencing of TAC1 in gastric cancer by promoter hypermethylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene biomarker for early detection and prognostication of gastric cancer
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    blocking the TAC1/TACR1 signaling system is a novel strategy for the treatment of pancreatic cancer
    ANIMAL & CELL MODELS