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FLASH GENE
Symbol TAAR1 contributors: mct - updated : 28-01-2012
HGNC name trace amine associated receptor 1
HGNC id 17734
Location 6q23.2      Physical location : 132.966.122 - 132.967.142
Synonym name trace amine receptor 1
Synonym symbol(s) TA1, TAR1, TRAR1, MGC126874, MGC138399, RP11-295F4.9
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text TARR cluster
STRUCTURE 1.02 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
Map cen - TAAR1 - TAAR2 - TAAR3 - TAAR4P - TAAR5 - TAAR6 - TAAR7P - TAAR8 - TAAR9 - qter
Authors Lindemann (05)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1020 - 339 - -
EXPRESSION
Rna function expression of the mRNAs encoding these trace amine receptors in leukocytes
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  lowly
 stomach   moderately
Nervousbraindiencephalonamygdala lowly Homo sapiens
Respiratorylung   lowly
Urinarykidney   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to rattus Tar1
homolog to murine Trar1
Homologene
FAMILY G-protein coupled receptor 1 family
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • may be mediated by the G(s)-class of G-proteins which activate adenylate cyclase
  • regulator of dopaminergic neurotransmission
  • tonically activates inwardly rectifying K(+) channels, which reduces the basal firing frequency of dopamine (DA) neurons of the ventral tegmental area (VTA)
  • plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants
  • role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity
  • is potentially a negative modulator of monoaminergic neurotransmission
  • affects the dopaminergic system by regulating the firing rate of dopaminergic neurons or by altering DRD2 responsiveness to ligands
  • TAAR1 and DRD2 have functional and physical interactions that could be critical for the modulation of the dopaminergic system by TAAR1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functional interaction between TAAR1 and DRD2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    antipsychotic and anxiolytic potential of TAAR1 agonists
    ANIMAL & CELL MODELS
  • Taar1 knockout mice display increased sensitivity to amphetamine as revealed by enhanced amphetamine-triggered increases in locomotor activity and augmented striatal release of dopamine compared with wild-type animals