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FLASH GENE
Symbol T contributors: SGE/npt - updated : 22-05-2008
HGNC name T, brachyury homolog (mouse)
HGNC id 11515
Location 6q27      Physical location : 166.571.085 - 166.582.131
Synonym name
  • transcription factor T
  • T protein
  • brachyury protein
    • Synonym symbol(s) TFT, locusT, MGC104817, TF
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D6S184 - IGF2R - D6S186 - TCP1 ,PLG PLG - T - D6S264 - D6S133 - TCP10 - D6S37 - qter
    Authors Morrison (96)
    Physical map
    C6orf118 6q27 chromosome 6 open reading frame 118 PDE10A 6q26 phosphodiesterase 10A LOC346085 6q27 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) T 6q27 T, brachyury homolog (mouse) MGC35308 6q27 hypothetical protein MGC35308 C6orf83 6q27 chromosome 6 open reading frame 83 BRP44L 6q27 brain protein 44-like RPS6KA2 6q27 ribosomal protein S6 kinase, 90kDa, polypeptide 2 RNASET2 6q27 ribonuclease T2 FGFR1OP 6q27 FGFR1 oncogene partner CCR6 6q27 chemokine (C-C motif) receptor 6 GPR31 6q27 G protein-coupled receptor 31 LOC389448 6 similar to T-complex protein 10A homolog LOC391986 6 similar to unc-93 homolog A UNC93A 6q27 unc-93 homolog A (C. elegans) C6orf104 LOC389449 6 LOC389449 TCP10 6q26 t-complex 10 (mouse) LOC391987 6 similar to Serine palmitoyltransferase 2 (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2) C6orf123 6q27 chromosome 6 open reading frame 123 MLLT4 6q27 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 LOC202546 6q27 hypothetical LOC202546 C6orf54 6q27 chromosome 6 open reading frame 54 KIF25 6q27 kinesin family member 25 FRMD1 6q27 FERM domain containing 1 LOC389450 6 LOC389450 LOC154323 6q27 hypothetical LOC154323 MGC33437 6q27 meningioma expressed antigen 6 (coiled-coil proline-rich) pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2518 47 435 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland highly
    Respiratorylung   highly
    cell lineage cells derived from the notochord
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • large N terminal DNA binding domain (T-box)
  • two pairs of transactivation and repression domains in the C terminus
    • mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine T (91.7pc)
    homolog to rattus T (92.2pc)
    Homologene
    FAMILY
  • brachyury protein family
    • CATEGORY DNA associated , transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in the transcription regulation of genes required for mesoderm formation and differentiation
  • nuclear transcription factor that binds to a specific DNA element, the palindromic T-site
  • may be a tumor suppressor gene in lung cancer
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • mesoderm development
  • determination of anterior/posterior axis, embryo
    • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding to palindromic T-site
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by methylation of the promoter in 80pc of primary lung adenocarcinoma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    low expressed in lung tumors
    Susceptibility
  • to spina-bifida (OMIM 182940)
  • to familial chordoma
    • Variant & Polymorphism SNP , other
  • TIVS7 T/C associated with the risk of spina-bifida
  • duplication in familial chordoma (Yang 2009)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • transgenic null allele mice (Abe, 2000)