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FLASH GENE

Symbol

T

contributors: mct - updated : 29-12-2016

HGNC name	T, brachyury homolog (mouse)
HGNC id	11515

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q27      Physical location : 166.571.085 - 166.582.131
Synonym name	transcription factor T
	T protein
	brachyury protein
Synonym symbol(s)	TFT, locusT, MGC104817, TF

DNA

TYPE	functioning gene
STRUCTURE	11.00 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	KDM6A and UTY bind directly to Brachyury (T) promoter and are required for WNT/CTNNB1 signaling-induced Brachyury expression in ES cells

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D6S184 - IGF2R - D6S186 - TCP1 ,PLG PLG - T - D6S264 - D6S133 - TCP10 - D6S37 - qter
Authors	Morrison (96)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 9 - 2518 47 435 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system breast mammary gland   highly Respiratory lung       highly

cell lineage	cells derived from the notochord
cell lines
fluid/secretion

at STAGE

physiological period

embryo

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	large N terminal DNA binding domain (T-box)
	two pairs of transactivation and repression domains in the C terminus

mono polymer

monomer

HOMOLOGY

interspecies	homolog to murine T (91.7pc)
	homolog to rattus T (92.2pc)

Homologene

FAMILY

brachyury protein family

CATEGORY

DNA associated , transcription factor , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	playing a role in the transcription regulation of genes required for mesoderm formation and differentiation
	nuclear transcription factor that binds to a specific DNA element, the palindromic T-site
	may be a tumor suppressor gene in lung cancer
	TBX2, TBX3, TBX4, TBX5 and three members of TBX1 (TBX1, TBX15, TBX18), Brachyury (T) and Eomes (TBR2) are expressed in the developing limb

CELLULAR PROCESS	cell life, differentiation
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	mesoderm development
	determination of anterior/posterior axis, embryo

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA	binding to palindromic T-site

RNA

small molecule

protein

cell & other

REGULATION

repressed by

methylation of the promoter in 80pc of primary lung adenocarcinoma

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   low expressed in lung tumors

Susceptibility

to spina-bifida (OMIM 182940) to familial chordoma

Variant & Polymorphism SNP , other	TIVS7 T/C associated with the risk of spina-bifida
	duplication in familial chordoma (Yang 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

transgenic null allele mice (Abe, 2000)