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FLASH GENE
Symbol T contributors: mct - updated : 29-12-2016
HGNC name T, brachyury homolog (mouse)
HGNC id 11515
Location 6q27      Physical location : 166.571.085 - 166.582.131
Synonym name
  • transcription factor T
  • T protein
  • brachyury protein
  • Synonym symbol(s) TFT, locusT, MGC104817, TF
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • KDM6A and UTY bind directly to Brachyury (T) promoter and are required for WNT/CTNNB1 signaling-induced Brachyury expression in ES cells
  • MAPPING cloned Y linked N status confirmed
    Map cen - D6S184 - IGF2R - D6S186 - TCP1 ,PLG PLG - T - D6S264 - D6S133 - TCP10 - D6S37 - qter
    Authors Morrison (96)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2518 47 435 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland highly
    Respiratorylung   highly
    cell lineage cells derived from the notochord
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • large N terminal DNA binding domain (T-box)
  • two pairs of transactivation and repression domains in the C terminus
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine T (91.7pc)
    homolog to rattus T (92.2pc)
    Homologene
    FAMILY
  • brachyury protein family
  • CATEGORY DNA associated , transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in the transcription regulation of genes required for mesoderm formation and differentiation
  • nuclear transcription factor that binds to a specific DNA element, the palindromic T-site
  • may be a tumor suppressor gene in lung cancer
  • TBX2, TBX3, TBX4, TBX5 and three members of TBX1 (TBX1, TBX15, TBX18), Brachyury (T) and Eomes (TBR2) are expressed in the developing limb
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • mesoderm development
  • determination of anterior/posterior axis, embryo
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding to palindromic T-site
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by methylation of the promoter in 80pc of primary lung adenocarcinoma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    low expressed in lung tumors
    Susceptibility
  • to spina-bifida (OMIM 182940)
  • to familial chordoma
  • Variant & Polymorphism SNP , other
  • TIVS7 T/C associated with the risk of spina-bifida
  • duplication in familial chordoma (Yang 2009)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • transgenic null allele mice (Abe, 2000)