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FLASH GENE
Symbol SYTL5 contributors: mct - updated : 22-04-2011
HGNC name synaptotagmin-like 5
HGNC id 15589
Location Xp21.1      Physical location : 37.865.834 - 37.988.072
Synonym symbol(s) SLP5
DNA
TYPE functioning gene
STRUCTURE 92.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC340571 Xp21.1 similar to hSIAH1 LOC392441 X similar to melanoma antigen LOC139604 Xp21.1 similar to hypothetical protein MGC33889 MGC34831 Xp21.1 hypothetical protein MGC34831 FLJ36601 Xp21.1 hypothetical protein FLJ36601 LOC158730 Xp21.1 hypothetical LOC158730 PRRG1 Xp21.1 proline-rich Gla (G-carboxyglutamic acid) polypeptide 1 LOC389844 X similar to ferritin, heavy polypeptide-like 17 LOC139249 Xp21.1 similar to hypothetical protein FLJ35782 FLJ42925 Xp21.1 FLJ42925 protein XK Xp21.1 Kell blood group precursor (McLeod phenotype) CYBB Xp21.1 cytochrome b-245, beta polypeptide (chronic granulomatous disease) TCTE1L Xp21.1 t-complex-associated-testis-expressed 1-like SC4MOP Xp21.1 sterol-C4-methyl oxidase pseudogene HYPM Xp21.1 sterol-C4-methyl oxidase pseudogene LOC340549 Xp21.1 similar to RIKEN cDNA 1700113O17 SYTL5 Xp21.1 synaptotagmin-like 5 SRPX Xp21.1 sushi-repeat-containing protein, X chromosome LOC286441 Xp21.1 hypothetical LOC286441 RPGR Xp21.1 retinitis pigmentosa GTPase regulator OTC Xp21.1 ornithine carbamoyltransferase LOC392442 X similar to BAG-family molecular chaperone regulator-1 (BCL-2 binding athanogene-1) (BAG-1) (Glucocorticoid receptor-associated protein RAP46) LOC392443 X similar to ferritin light chain LOC392444 X similar to Nucleolar transcription factor 1 (Upstream binding factor 1) (UBF-1) TM4SF2 Xp11.4-q11 transmembrane 4 superfamily member 2 LOC389845 X LOC389845 STRAIT11499 Xp11.4 hypothetical protein STRAIT11499 LOC389846 X hypothetical gene supported by BC043536 GAPDP1 Xp11.4-p11.23 glyceraldehyde-3-phosphate dehydrogenase pseudogene 1 LOC392445 X similar to 40S ribosomal protein S11 BCOR Xp11.4 BCL6 co-repressor LOC158624 Xp11.4 similar to IMP dehydrogenase (EC 1.1.1.205) I - human
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an intravesicular N terminal domain made of two conserved regions SHD1 and SHB2 fonctioning as protein interaction sites,a single transmembrane (TM) region,two protein kinase C-homologous repeats (Ca2+ binding domains C2) and a conserved WHXL motif in the C terminus
HOMOLOGY
Homologene
FAMILY
  • C type tandem C2 protein family (SLP family)
  • synaptotagmin family
  • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • involved in RAB27A dependent membrane trafficking in specific tissues
  • with SYT7, are positive regulators of chemotaxis (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular trafficking
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein RAB27A (GTP bound form) binding
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS