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FLASH GENE

Symbol

SYTL4

contributors: mct - updated : 14-02-2014

HGNC name	synaptotagmin-like 4
HGNC id	15588

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xq22.1      Physical location : 99.929.490 - 99.987.135
Synonym name	granuphilin a
	exophilin-2
Synonym symbol(s)	DKFZp451P0116, SLP4, FLJ40960

DNA

TYPE	functioning gene
STRUCTURE	57.65 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	promoter is a target of SREBF1, a transcription factor that controls fatty acid synthesis, and MAFA, a beta cell differentiation factor

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_080737 19 - 3936 NP_542775 - 671 - 1999 10497219 NM_001174068 17 - 3767 NP_001167539 - 671 - 1999 10497219 NM_001129896 18 - 3888 NP_001123368 - 671 - 1999 10497219

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular heart       highly Endocrine adrenal gland         Homo sapiens   neuroendocrine pituitary       Homo sapiens Nervous brain         Homo sapiens Reproductive male system prostate     moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic platelet Homo sapiens Endocrine islet cell (alpha,beta...) Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

neonatal

Text	umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal Slp homology domain
	made of two conserved region SHD/SH2 linked together
	two protein KC conserved region to (CALCB) C2 at the C terminus

HOMOLOGY

interspecies

homolog to murine Sytl4

Homologene

FAMILY	synaptotagmin C2 domain containing protein family
	Rab27a effector family proteins

CATEGORY

regulatory , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	synaptic vesicles
	endogenous platelet SYTL4 and RAB8A colocalized in the center of activated platelets, where granule secretion takes place

basic FUNCTION	regulated exocytosis in endocrine tissues
	modulates amylase release from parotid acinar cells through interaction with syntaxin-2/3 on the apical plasma membrane
	control potentially insulin secretion through interaction with STX1A and/or STXBP2
	crucial component of the docking machinery of insulin-containing vesicles to the plasma membrane
	STXBP1 and SYTL4 collaborate in the docking of insulin granules to the plasma membrane in an initial fusion-incompetent state, with STXBP1 subsequently playing a positive role in a later stage of insulin granule exocytosis
	SYTL4 and RAB8A enhance dense granule release and the SYTL4 effect is dependent on RAB8A binding
	SYTL4 and SYTL1 differentially regulate the exocytosis of either stably or minimally docked granules, respectively

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	vesicular transport

PATHWAY

metabolism

signaling

activation of the SREBF1/SYTL4 pathway is a potential mechanism for impaired insulin secretion in diabetes, contributing to beta cell lipotoxicity

a component

INTERACTION

DNA

RNA

small molecule

protein	binding RAB27A/B (GTP bound form)
	SYTL4 and EXPH5 are RAB27A and RAB27B effectors
	binds to syntaxin-2 and syntaxin-3 as well as STX1A, and likely mediates granule docking through interactions with those multiple syntaxins on the plasma membrane
	SYTL4 and RAB8A are expressed and interact in human platelets, and might be involved in dense granule release
	RAB27A-SYTL4 complex on WPB (Weibel-Palade body) promotes exocytosis through an interaction with STXBP1, thereby controlling the release of vaso-active substances in the vasculature

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS