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FLASH GENE
Symbol SYTL2 contributors: mct - updated : 15-11-2018
HGNC name synaptotagmin-like 2
HGNC id 15585
Location 11q14.1      Physical location : 85.405.266 - 85.522.178
Synonym name
  • exophilin-4
  • chromosome 11 synaptotagmin
  • breast cancer-associated antigen SGA-72M
  • Synonym symbol(s) SLP2, CHR11SYT, FLJ20163, FLJ21219, KIAA1597, SGA72M, MGC102768, EXO4, FLJ42764, FLJ45597, FLJ34802, PPP1R151, SLP2A
    DNA
    TYPE functioning gene
    STRUCTURE 63.78 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 splicing 4280 102.4 910 - 2014 24284068
    encoding the longer isoform with at least 19 exons and sharing the last 8 exons with variant b
    9 splicing 2401 42.6 376 - 2014 24284068
    using the last 8 exons of transcript variant a and containing an internal unique exon
    13 - 4807 141.6 1272 - 2014 24284068
    12 - 4759 139.7 1256 - 2014 24284068
    12 - 2432 42.6 376 - 2014 24284068
    9 - 2622 41.4 365 - 2014 24284068
    10 - 2672 38.4 336 - 2014 24284068
    17 - 4142 104.8 934 - 2014 24284068
  • isoform Slp2a-hem
  • associates with RAB27a in cytotoxic T cells and participates to cytotoxic granule secretion (PMID: 18812475)
  • 18 - 4060 105 935 - 2014 24284068
    19 - 3951 - 902 - 2014 24284068
    11 - 2785 - 255 - 2014 24284068
    11 - 2356 - 336 - 2014 24284068
    19 - 4287 - 911 - 2014 24284068
    18 - 3794 - 862 - 2014 24284068
    10 - 2469 - 376 - 2014 24284068
    11 - 2323 - 376 - 2014 24284068
    11 - 2517 - 376 - 2014 24284068
    8 - 2254 - 325 - 2014 24284068
    7 - 2083 - 268 - 2014 24284068
    10 - 2228 - 365 - 2014 24284068
    8 - 2203 - 308 - 2014 24284068
    11 - 2319 - 429 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal Slp homology domain
  • made of two conserved region SHD/SH2 linked together
  • two protein KC conserved region to (CALCB) C2 at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • synaptotagmin, C2 domain containing protein family
  • CATEGORY regulatory , secretory , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text synaptic vesicles
    basic FUNCTION
  • both SYTL1 and SYTL2 may form part of a docking complex, capturing secretory lysosomes at the immunological synapse
  • is required for cytotoxic granule docking at the immunologic synapse
  • functions as a low affinity, fast exocytic Ca(2+) sensor in neurons, where it is activated by Ca(2+) influx through voltage-gated channels
  • can serve as an exocytic sensor for diverse Ca(2+) signaling systems, and its levels are limiting for stimulated secretory function in airway goblet cells
  • is required for stress-induced mitochondrial hyperfusion
  • is required for targeting of the signaling molecule podocalyxin to the apical membrane in a RAB27A-dependent manner
  • controls renal cell size through regulation of Rap-ezrin signaling independently of RAB27A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular traffick
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding RAB27A/B (GTP bound form)
  • CALM1 suppresses SYTL2 transcription in cortical neurons
  • SYTL2 is a RAB27A effector protein that regulates transport of RAB27A-bearing vesicles and organelles through its N-terminal RAB27A-binding domain and a phospholipid-binding C2A domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    promoted metastatic potential, including increased migration and invasiveness in the ovarian carcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS