Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SYTL1 contributors: np/mct - updated : 16-06-2015
HGNC name synaptotagmin-like 1
HGNC id 15584
Location 1p36.11      Physical location : 27.668.482 - 27.680.421
Synonym name
  • NADPH oxidase-related, C2 domain-containing protein
  • exophilin-7
  • NADPH oxidase-related, C2 domain-containing protein
  • protein JFC1
  • Synonym symbol(s) FLJ14996, JFC1, FLJ14996, SLP1
    DNA
    TYPE functioning gene
    STRUCTURE 11.94 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 1989 61.7 562 - 2001 11327731
    15 - 1946 60.5 550 - 2001 11327731
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly Homo sapiens
     pancreasislet of Langerhans  highly Homo sapiens
    Lymphoid/Immunethymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Digestiveacinar Homo sapiens
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal SLP homology domain (SHD) with two conserved regions SHD1 and SHD2 linked together functioning as protein interaction sites
  • two protein kinase C conserved region 2 (Calb) C2 at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • C type tandem C2 protein family (SLP family)
  • Rab27a effector family proteins
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • co-localized with RAB27B on zymogen granules
  • located on insulin granules
  • basic FUNCTION
  • adaptor between PI3 kinase product and the oxidase cytosolic complex
  • differentially regulating the secretion of PSA (prostate-specific antigen) and PSAP (prostatic-specific acid phosphatase)
  • RAB27A-binding protein, which regulates androgen-dependent secretion of prostate-specific antigen and
  • prostatic-specific acid phosphatase
  • both SYTL1 and SYTL2 may form part of a docking complex, capturing secretory lysosomes at the immunological synapse
  • key components of the secretory machinery that regulates exocytosis in prostate carcinoma cells
  • putative RAB27B effector protein and implicated in intracellular membrane transport
  • part of the machinery of amylase secretion by the exocrine pancreas
  • inhibits dense granule secretion in platelets and RAP1GAP2 modulates secretion by binding to SYTL1
  • during exocytosis, secretory granules use a SYTL1- and GMIP-dependent molecular mechanism to traverse cortical actin
  • decreases dense granule release in platelets
  • appears to mediate the fusion of undocked granules through the affinity of its C2A domain toward the plasma membrane phospholipids
  • SYTL4 and SYTL1 differentially regulate the exocytosis of either stably or minimally docked granules, respectively
  • actively mediates the exocytosis of undocked granules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GTP domain of RAB27A (Rab27a-binding protein)
  • interacted with RAB27B
  • TBC1D10A interacts with SYTL1 to coordinate RAB8A and ARF6 membrane trafficking
  • GMIP is a factor that associates with the RAB27A effector SYTL1 and modulates vesicular transport and exocytosis
  • RHOA activity polarizes around SYTL1-containing secretory granules, suggesting that it may control directionality of granule movement
  • putative RAB27A effector family proteins, SYTL1/JFC1/Slp1, is expressed in beta cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • exophilin7-null mice exhibit no gross alterations in glucose tolerance or insulin secretion at the body level