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FLASH GENE
Symbol SYT7 contributors: mct/npt/pgu - updated : 28-03-2018
HGNC name synaptotagmin VII
HGNC id 11514
Location 11q12.2      Physical location : 61.282.787 - 61.348.298
Synonym name
  • prostate cancer associated protein 7
  • synaptotagmin 7
  • Synonym symbol(s) IPCA-7, PCANAP7, SYT-VII, MGC150517
    DNA
    TYPE functioning gene
    STRUCTURE 65.51 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see CD6
    Physical map
    LOC255714 11q12.2 similar to ZP1 precursor NMP200 11q12.2 nuclear matrix protein NMP200 related to splicing factor PRP19 MGC5508 11q12.2 hypothetical protein MGC5508 GBP 11q12.2 likely ortholog of rat GRP78-binding protein SLC15A3 11q13.1 solute carrier family 15, member 3 CD6 11q13 CD6 antigen CD5 11q12.2 CD5 antigen (p56-62) FLJ20847 11q12.3 hypothetical protein FLJ20847 PGA5 11q13 pepsinogen 5, group I (pepsinogen A) FLJ32009 11q12.3 hypothetical protein FLJ32009 DDB1 11q12-q13.1 damage-specific DNA binding protein 1, 127kDa DKFZP586B1621 11q12.3 DKFZP586B1621 protein MGC20446 11q12.3 hypothetical protein MGC20446 HSPC196 11q12.3 hypothetical protein HSPC196 MGC:13379 11q13.1 HSPC244 FLJ12529 11q12.3 pre-mRNA cleavage factor I, 59 kDa subunit FLJ20487 11q12.3 hypothetical protein FLJ20487 FLJ32771 11q12.3 IIIG9 protein SYT7 11q12-q13.1 synaptotagmin VII LOC390205 11 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 RPLP0P2 11cen-q12 ribosomal protein, large, P0 pseudogene 2 C11orf11 11q13.1 chromosome 11 open reading frame 11 C11orf9 11q12-q13.1 chromosome 11 open reading frame 9 C11orf10 11q12-q13.1 chromosome 11 open reading frame 10 FEN1 11q13.1 flap structure-specific endonuclease 1 FADS1 11q12.2-q13.1 fatty acid desaturase 1 FADS2 11q12-q13.1 fatty acid desaturase 2 FADS3 11q12-q13.1 fatty acid desaturase 3 RAB3IL1 11q12-q13.1 RAB3A interacting protein (rabin3)-like 1 VMD2 11q12-q13.1 vitelliform macular dystrophy (Best disease, bestrophin) FTH1 11q13.1 ferritin, heavy polypeptide 1 LOC387774 11 LOC387774 LOC390206 11 similar to 40S ribosomal protein S2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4609 - 403 - 2002 12071850
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
    Reproductivefemale systemplacenta  highly
     male systemprostate  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an intravesicular N terminal domain
  • a single transmembrane (TM) region
  • two protein kinase C-homologous repeats (Ca2+ binding domains C2), C2A and C2B domains that exhibit Ca2+-dependent phospholipid binding, and both contribute to exocytosis
  • a conserved WHXL motif in the C terminus
  • mono polymer homomer , heteromer , complex
    HOMOLOGY
    interspecies homolog to murine Syt7
    ortholog to rattus Syt7
    Homologene
    FAMILY
  • synaptotagmin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    text
  • membrane of synaptic vesicles
  • is abundantly distributed in neuropil of all examined anatomical areas of the brain, most prominently in axons
  • basic FUNCTION
  • calcium sensor for transmitter release at the central synapse, involved in exocytosis and endocytosis
  • serves as a Ca(2+) sensor in the release of neurotransmitters and hormone
  • may be involved in the control of synaptic neuropeptide release or some other form of Ca2+-induced exocytosis
  • major Ca2+ sensor for exocytosis in chromaffin cells, which, together with synaptotagmin-1, mediates almost all of the Ca2+ triggering of exocytosis in these cells
  • functioning by binding to Ca2+ and, thus in this sense, is a Ca2+ sensor
  • acting to trigger exocytosis in a manner similar to synaptotagmin-1, by binding to phospholipids and SNARE proteins
  • plays an important role in bone remodeling and homeostasis by modulating secretory pathways functionally important in osteoclasts and osteoblasts
  • principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas
  • Ca(2+) sensor of dense core vesicles fusion machinery (
  • with SYTL5, are positive regulators of chemotaxis
  • Ca(2+) sensor that regulates lysosome exocytosis and plasma membrane repair
  • controls fusion pore dynamics during exocytosis via a push-and-pull mechanism in which Ca2+ binding to both C2 domains promotes fusion pore opening, but the C2B domain is selectively essential for continuous expansion of an otherwise unstable fusion pore
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system , exocytosis transport , endocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • multifunctional intrinsic membrane protein of synaptic vesicles of neurons and chromaffin granules
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • role for the SYT7-phosphatidylserine interaction in stabilizing open fusion pores (
  • palmitoylation-dependent association with the tetraspanin CD63 is the mechanism by which SYT7 is targeted to lysosomes
  • SYT7 interacts with Synaptotagmin-binding, cytoplasmic RNA-interacting protein (SYNCRIP)
  • possible functional connection between SYT7 and SYNCRIP proteins in Purkinje neurons
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate Ca2+ sensor for exocytosis that is at least partly localized to synapses
    Marker
    Therapy target
    ANIMAL & CELL MODELS