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FLASH GENE
Symbol SYT5 contributors: mct - updated : 14-12-2009
HGNC name synaptotagmin V
HGNC id 11513
Location 19q13.42      Physical location : 55.684.468 - 55.691.720
Synonym symbol(s) SYTG5, SytV
DNA
TYPE functioning gene
STRUCTURE 7.25 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388562 19 similar to 1060P11.4.2 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (isoform 2) (KIR103-AS)) KIR3DL1 19q13.4 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 KIR2DS4 19q13.4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 FCAR 19q13.4 Fc fragment of IgA, receptor for NCR1 19q13.42 natural cytotoxicity triggering receptor 1 NALP7 19q13.42 NACHT, leucine rich repeat and PYD containing 7 NALP2 19q13.42 NACHT, leucine rich repeat and PYD containing 7 GP6 19q13.4 glycoprotein VI (platelet) RDH13 19q13.42 retinol dehydrogenase 13 (all-trans and 9-cis) EPS8L1 19q13.42 EPS8-like 1 PPP1R12C 19q13.42 protein phosphatase 1, regulatory (inhibitor) subunit 12C TNNT1 19q13.4 troponin T1, skeletal, slow TNNI3 19q13.4 troponin I, cardiac LOC352909 19q13.4 similar to hypothetical testis protein from macaque SYT5 19q13.4 synaptotagmin V PTPRH 19q13.4 protein tyrosine phosphatase, receptor type, H LOC388563 19 LOC388563 MGC30208 19q13.42 hypothetical protein MGC30208 KIAA1115 19q13.42 KIAA1115 HSPBP1 19q13.42 hsp70-interacting protein KIAA1811 19q13.4 KIAA1811 protein LOC284417 19q13.42 similar to BC022651 protein MGC2705 19q13.42 hypothetical protein MGC2705 COXVIB2 19q13.42 cytochrome c oxidase subunit VIb, testes-specific MGC35045 19q13.42 hypothetical protein MGC35045 IL11 19q13.4 interleukin 11 MDAC1 19q13.42 MDAC1 LOC388564 19 hypothetical gene supported by BC052596 RPL28 19q13.4 ribosomal protein L28
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1853 - 386 - -
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an intravesicular N terminal domain
  • a single transmembrane (TM) region
  • two protein kinase C-homologous repeats (Ca2+ binding domains C2)
  • a conserved WHXL motif in the C terminus
  • mono polymer homomer , heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Syt5
    ortholog to C.elegans f31e8.2
    ortholog to rattus Syt5
    Homologene
    FAMILY
  • synaptotagmin family
  • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    basic FUNCTION
  • calcium sensor for transmitter release at the central synapse, involved in exocytosis and endocytosis
  • SYT3, SYT5, SYT6, and SYT10 exhibit similar Ca2+-dependent phospholipid- and SNARE-binding properties as SYT1, although with a higher apparent Ca2+-affinity
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS nervous system , exocytosis transport , endocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • multifunctional intrinsic membrane protein of synaptic vesicles of neurons and chromaffin granules
  • SYT10 belongs to a group of Ca2+-binding synaptotagmins that includes SYT3, SYT5, and SYT6, and that differs from the group containing SYT1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS