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FLASH GENE
Symbol SYT15 contributors: - updated : 27-10-2004
HGNC name synaptotagmin XV
HGNC id 17167
Location 10q11.1      Physical location : 46.955.443 - 46.970.601
Synonym name chr10 synaptotagmin
Synonym symbol(s) CHR10SYT, sytXV
DNA
TYPE functioning gene
STRUCTURE 15.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC387662 10 hypothetical gene supported by BX538120 RASSF4 10q11.21 Ras association (RalGDS/AF-6) domain family 4 C10orf10 10q11.21 chromosome 10 open reading frame 10 C10orf25 10q11.21 chromosome 10 open reading frame 25 ZNF22 10q11.2 zinc finger protein 22 (KOX 15) LOC340765 10q11.21 similar to double homeobox, 4; double homeobox protein 4 LOC387663 10 similar to cubilin; intrinsic factor-cobalamin receptor; intrinsic factor B12-receptor LOC389957 10 similar to breast cancer antigen NY-BR-1.1 LOC389958 10 similar to cubilin; intrinsic factor-cobalamin receptor; intrinsic factor B12-receptor LOC220974 10q11.21 similar to olfactory receptor GA_x54KRFPKN04-58149882-58150865 OR13A1 10q22.2 olfactory receptor, family 13, subfamily A, member 1 ALOX5 10q11.2 arachidonate 5-lipoxygenase MIR 10q11.22 c-mir, cellular modulator of immune recognition LOC387664 10 LOC387664 ANUBL1 10q11.22 AN1, ubiquitin-like, homolog (Xenopus laevis) LOC143158 10q11.22 similar to ARF GTPase-activating protein LOC389959 10 similar to KIAA0592 protein KIAA0592 10q11.1 KIAA0592 protein MRIP2 10q11.22 ARF GTPase-activating protein LOC389960 10 hypothetical gene supported by AY258587; NM_003631 LOC387665 10 similar to ARF GTPase-activating protein LOC387666 10 similar to Ribosome biogenesis protein BMS1 homolog LOC389961 10 hypothetical gene supported by L25628 RHEBP1 10q11 Ras-homolog enriched in brain pseudogene 1 SYT15 10q11.1 synaptotagmin XV PPYR1 10q11.2-q21.2 pancreatic polypeptide receptor 1 LOC387667 10 hypothetical gene supported by BC004945; NM_002136 LOC220466 10q11.22 similar to ARF GTPase-activating protein LOC340733 10q11.22 similar to Dual specificity phosphatase 8 CTSLL2 10q22 cathepsin L-like 2 LOC340844 10q11.22 similar to Ahcy protein LOC195977 10q11.22 hypothetical protein LOC195977 LOC387668 10 similar to ARF GTPase-activating protein ANXA8 10q11.2 annexin A8 FLJ10824 10q11.22 hypothetical protein FLJ10824 LOC389963 10 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) LOC387669 10 LOC387669 LOC387670 10 hypothetical gene supported by NM_133446 ZNF488 10q11.22 zinc finger protein 488 RBP3 10q11.2 retinol binding protein 3, interstitial GDF2 10q11.22 growth differentiation factor 2 GDF10 10q21.1 growth differentiation factor 10
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4862 47 421 - Fukuda
isoform a contains two C2 domains
- - 1536 - 390 - Fukuda
variant b contains an alternate 3' sequence (lacks exon 8), resulting in isoform b which lacks a C2 domain
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrainhindbraincerebellum  
 braindiencephalonthalamus  
Reproductivemale systemtestis  predominantly
Respiratorylung   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal transmembrane domain
  • putative fatty-acylation sites
  • two C-terminal tandem C2 domains
  • HOMOLOGY
    interspecies homolog to murine Syt15
    homolog to rattus sytXV
    Homologene
    FAMILY synaptotagmin family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text type III transmembrane protein
    basic FUNCTION may be involved in the trafficking and exocytosis of secretory vesicles in non neuronal tissues
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    phospholipid binding in a Ca2+ independent manner
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS