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FLASH GENE

Symbol

SYNPO2L

contributors: npt - updated : 26-05-2006

HGNC name	synaptopodin 2-like
HGNC id	23532

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q22.2      Physical location : 75.404.644 - 75.415.832
Synonym name	fesselin
Synonym symbol(s)	FLJ12921, SYNOP2L

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 4933 102 977 - Deloukas (2004) variant 2 - - 4131 - 753 - Deloukas (2004)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Respiratory respiratory tract larynx

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains	rich in proline and containing multiple PXXP motifs that could function as potential peptide ligand motifs for SH3 domain containing proteins
	one PPXY motif

HOMOLOGY

intraspecies

homolog to synaptopodin

Homologene

FAMILY

synaptopodin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus
text	localized in dense bodies and in Z-lines of striated muscle

basic FUNCTION	increases the rate of actin polymerization by accelerating the nucleation phase and exhibits a high potency to bundle actin filaments
	playing a role in organizing cellular actin
	may be stabilizing the formation of actin nuclei

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the cytoskeleton

INTERACTION

DNA

RNA

small molecule

protein	interact with calmodulin in a Ca2+-dependent manner
	actin binding protein
	multiple binding partners including myosin, calmodulin and alpha-actinin

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS