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FLASH GENE
Symbol SYNPO2L contributors: npt - updated : 26-05-2006
HGNC name synaptopodin 2-like
HGNC id 23532
Location 10q22.2      Physical location : 75.404.644 - 75.415.832
Synonym name fesselin
Synonym symbol(s) FLJ12921, SYNOP2L
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
NUDT13 10q22.3 nudix (nucleoside diphosphate linked moiety X)-type motif 13 HSGT1 10q22.3 nudix (nucleoside diphosphate linked moiety X)-type motif 13 DNAJC9 10q22.3 DnaJ (Hsp40) homolog, subfamily C, member 9 MRPS16 10q22.1 mitochondrial ribosomal protein S16 LOC118491 10q22.3 tetratricopeptide repeat-containing protein ANXA7 10q21.1-q21.2 annexin A7 ZMYND17 10q22.3 zinc finger, MYND domain containing 17 PPP3CB 10q22.3 protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) C10orf29 MYOZ1 10q22.1 myozenin 1 SYNPO2L 10q22.3 synaptopodin 2-like LOC118704 10q22.3 similar to ARF GTPase-activating protein LOC389978 10 similar to Ribosome biogenesis protein BMS1 homolog GLUDP3 10q22.1 glutamate dehydrogenase pseudogene 3 SEC24C 10q22.3 SEC24 related gene family, member C (S. cerevisiae) FUT11 10q22.3 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) LOC118487 10q22.3 similar to RIKEN cDNA 1110001O19 LOC196752 10q22.3 similar to CG32542-PA KIAA0913 10q22.3 KIAA0913 protein NDST2 10q22 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 CAMK2G 10q22.3 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma PLAU 10q23.3-q24.3 plasminogen activator, urokinase VCL 10q22.1-q23 vinculin AP3M1 10q22.3 adaptor-related protein complex 3, mu 1 subunit
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4933 102 977 - Deloukas (2004)
- - 4131 - 753 - Deloukas (2004)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • rich in proline and containing multiple PXXP motifs that could function as potential peptide ligand motifs for SH3 domain containing proteins
  • one PPXY motif
    • HOMOLOGY
    intraspecies homolog to synaptopodin
    Homologene
    FAMILY
  • synaptopodin family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text localized in dense bodies and in Z-lines of striated muscle
    basic FUNCTION
  • increases the rate of actin polymerization by accelerating the nucleation phase and exhibits a high potency to bundle actin filaments
  • playing a role in organizing cellular actin
  • may be stabilizing the formation of actin nuclei
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the cytoskeleton
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with calmodulin in a Ca2+-dependent manner
  • actin binding protein
  • multiple binding partners including myosin, calmodulin and alpha-actinin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS