basic FUNCTION
| polyphosphoinositide phosphatase, key factor controlling the level of PtdIns(4,5)P2 required for proper neurotransmission |
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playing an essential role in synaptic vesicle recycling |
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acting as a negative regulator of clathrin coats |
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playing a role in neurological manifestations in Down syndrome |
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also required for normal vesicle endocytosis (Mani 2007) |
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playing a critical role for retrieval of membrane in order to maintain the quantity, timing of fusion, and spontaneous release properties of synaptic vesicles at hair-cell ribbon synapses  |
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major regulators of inositol metabolism and signaling in the brain and involved in astrogliogenesis  |
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may have a possible role for astrocytes or astrogliogenesis in Doiwn syndrome  |
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polyphosphoinositide phosphatase involved in clathrin-mediated endocytosis in conventional synapses  |
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acts with membrane curvature generators/sensors, such as the BAR protein endophilin, to preferentially remove PI(4,5)P2 from curved membranes as opposed to relatively flat ones  |
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key regulator of the signalling phospholipid phosphatidylinositol-4,5-biphosphate that regulate clathrin-mediated endocytosis  |
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involvement of SYNJ1 in endosomal abnormalities is consistent with the finding that the 145 kDa isoform interacts with endocytic SH3 domain-containing proteins, such as endophilin, amphiphysin and intersectin |