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FLASH GENE
Symbol SYNGR1 contributors: - updated : 28-08-2007
HGNC name synaptogyrin 1
HGNC id 11498
Location 22q13.1      Physical location : 39.745.953 - 39.781.591
Synonym symbol(s) MGC1939
DNA
TYPE functioning gene
STRUCTURE 35.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - PDGFB - SYNGR1 - MAP3K7IP1 - MGAT3 - ATF4 - D2S274 - qter
Authors Kedra (98)
Physical map
APOBEC3A 22q13.1-q13.2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A APOBEC3B 22q12-q13 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B APOBEC3C 22q12-q13 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C APOBEC3D 22q12-q13 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D APOBEC3E 22q12-q13 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3E pseudogene APOBEC3F 22q12-q13 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F APOBEC3G 22q12-q13 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G ARP10 22q13.1 ARP10 protein COX5BL7 22pter-p13 cytochrome c oxidase subunit Vb-like 7 CBX7 22q13.1 chromobox homolog 7 LOC391332 22 similar to hepatitis C virus core-binding protein 6; cervical cancer oncogene 3 FLJ23865 22q13.1 hypothetical protein FLJ23865 PDGFB 22q13.1 platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) RPL3 22q13.1 ribosomal protein L3 SYNGR1 22q13.1 synaptogyrin 1 MAP3K7IP1 22q13.1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 LOC388902 22 LOC388902 MGAT3 22q13.1 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase FLJ20232 22q13 hypothetical protein FLJ20232 ATF4 22q13.1 activating transcription factor 4 (tax-responsive enhancer element B67) MGC52010 22q13.2 hypothetical protein MGC52010 CACNA1I 22q13.1 calcium channel, voltage-dependent, alpha 1I subunit
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4425 - 234 - Kedra, Chi
exons 1, 3, 4, 6
- splicing 1329 - 191 heart, skeletal muscle Kedra, Chi
exons 1, 3, 4, 5
- splicing 825 - 192 ovary, fetal liver Kedra, Chi
exons 2, 3, 4, 5
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
 nervecranial nerve  highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane segments with cytoplasmic N and C termini
  • two conserved cysteine residues between TM1 and TM2
  • a MARVEL domain
  • HOMOLOGY
    interspecies homolog to murine syngr1
    Homologene
    FAMILY synaptogyrin family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • vesicle protein of synaptic vesicles
  • associated with presynaptic vesicles in neuronal cells
  • basic FUNCTION
  • involved in synaptic plasticity without being required for synaptic transmission
  • involved in presynaptic pathways, and may be in the pathogenesis of schizophrenia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia (SCZ) and bipolar disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS