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FLASH GENE
Symbol SYNCRIP contributors: mct/npt - updated : 28-03-2018
HGNC name synaptotagmin binding, cytoplasmic RNA interacting protein
HGNC id 16918
Location 6q14.3      Physical location : 86.317.502 - 86.353.043
Synonym name
  • NS1-associated protein 1
  • heterogeneous nuclear ribonucleoprotein Q
  • glycine- and tyrosine-rich RNA-binding protein
  • Synonym symbol(s) GRY-RBP, PP68, NSAP1, HNRPQ1, dJ3J17.2, hnRNP-Q, RP1-3J17.2, GRYRBP, HNRNPQ
    DNA
    TYPE functioning gene
    STRUCTURE 36.08 kb     11 Exon(s)
    regulatory sequence Binding site
    text structure RNA binding protein, 10 coding exons
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3194 69.5 623 - 2016 27081926
    12 - 7337 - 562 - 2016 27081926
    11 - 6774 - 464 - 2016 27081926
    11 - 6716 - 410 - 2016 27081926
    12 - 6797 - 527 - 2016 27081926
    11 - 6805 - 561 - 2016 27081926
    10 - 2560 - 588 - 2016 27081926
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     liver    
    Lymphoid/Immunelymph node   highly
    Nervousbrainhindbraincerebellum highly Homo sapiens
     brainlimbic systemhippocampus   Homo sapiens
    Reproductivefemale systemuterus  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three globular RNA-recognition motifs (RRM) domains flanked by an N-terminal acid-rich acidic sequence segment domain (AcD12-97 )
  • four ribonucleoprotein domains
  • an Arg/Gly-rich region
  • an acidic domain having structural similarity to Barstar and binding to APOBEC1
  • a C-terminal domain containing an arginine-glycine-rich sequence motif (RGG/RXG box), which are located near to the N- and C-terminals, respectively
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm
    text
  • mainly found at cell bodies, but punctate expression patterns in the proximal dendrite were also seen
  • had cytoplasmic somatodendritic pattern of expression, which was most prominent in the hippocampus and cerebellum
  • basic FUNCTION
  • regulating the splicing and /or transport of mRNAs from the nucleus to the cytoplasm
  • transported within the dendrite as a component of mRNA granules and involved in mRNA turnover in mRNA granules and in the regulation of local protein synthesis in neuronal dendrites
  • has dual functions, participating in both RNA replication and translation in Hepatitis C virus life cycle (Liu 2009)
  • specific role for SYNCRIP in neuronal morphogenesis
  • SYNCRIP-regulated CYBB mRNA degradation mediates the hypoinflammatory phase of sepsis
  • RNA-binding protein SYNCRIP is a component of the hepatocyte exosomal machinery controlling microRNA sorting
  • is a new RNA-binding proteins (RBPs) that controls the myeloid leukemia stem cell program
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • editosome complex
  • component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites
  • INTERACTION
    DNA
    RNA RNA interacting protein
    small molecule
    protein
  • APOBEC1 (interaction is regulated by the Acidic domain phosphorylation)
  • interacting with SMN2 (modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2 gene)(Chen 2008)
  • POLR2A
  • cellular function for SYNCRIP in the control of dendritic development and focal adhesion formation that involves the negative regulation of RHOA synthesis and signaling
  • may participate in localization of mRNAs encoding CCDC42 signaling factors in neurites, and thereby may regulate actin dynamics and control neuronal morphogenesis
  • changes in cytosolic SYNCRIP levels contribute to cell cycle-dependent translational differences in TP53 mRNA
  • is involved in viral replication, neural morphogenesis, modulation of circadian oscillation, and the regulation of the cytidine deaminase APOBEC1
  • SYT7 interacts with Synaptotagmin-binding, cytoplasmic RNA-interacting protein (SYNCRIP)
  • possible functional connection between SYT7 and SYNCRIP proteins in Purkinje neurons
  • SYNCRIP and MSI2 interact indirectly though shared mRNA targets (SYNCRIP maintains HOXA9 translation, and MSI2 or HOXA9 overexpression rescued the effects of SYNCRIP depletion)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS