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FLASH GENE
Symbol SYNC contributors: npt/mct - updated : 26-11-2021
HGNC name syncoilin, intermediate filament 1
HGNC id 28897
Location 1p35.1      Physical location : 33.145.506 - 33.168.361
Synonym name
  • intermediate filament protein syncoilin
  • syncoilin-1
  • Synonym symbol(s) SYNC1, SYNCOILIN, MGC149625, MGC149626
    DNA
    TYPE functioning gene
    STRUCTURE 14.90 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3503 - 482 - 2002 11694502
    4 - 3423 - 476 - 2002 11694502
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
     vesselsaorta   
    Endocrinepancreas    
     thyroid    
    Lymphoid/Immunethymus   highly
    Reproductivemale systemtestis  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumcardiac   Homo sapiens
    Muscularstriatumskeletal   Homo sapiens
    Nervouscentral    Homo sapiens
    Nervousperipherous    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family, type IV
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nuclear envelope
    text
  • atypical type III intermediate filament (IF) protein
  • basic FUNCTION
  • may be involved in the anchoring of the desmin intermediate filament network at the sarcolemma and the neuromuscular junction
  • may have a role in linking the desmin-associated intermediate filament network of the muscle fiber with the dystrophin-associated protein complex (DAPC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha dystrobrevin (interaction with alpha-dystrobrevin for maintenance and maturation of the synapse)
  • desmin in skeletal muscle
  • syncoilin might function to modulate formation of PRPH filament networks through binding to peripherin isoforms
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer tissues associated with a poorer overall survival and poorer postprogression survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serve as a prognostic marker in gastric cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    therapeutic target in gastric cancer
    ANIMAL & CELL MODELS