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FLASH GENE

Symbol

SYN3

contributors: - updated : 19-10-2005

HGNC name	synapsin III
HGNC id	11496

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q12.3      Physical location : 32.908.541 - 33.454.377

DNA

TYPE	functioning gene
STRUCTURE	494.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed SYN3a - - 2918 63 581 - Porton SYN3b - - 2830 - 439 fetal brain and adult Porton SYN3c - - 2626 - 444 brain Porton SYN3d - - - - - fetal brain only Porton SYN3e - - - - - non neuronal Porton SYN3f - - - - - non neuronal Porton

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen         Nervous brain         Reproductive male system testis       Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three conserved domains of the family, the phosphorylated A domain at the N terminus,
	the large ATP binding, C domain,inhibited by Ca2+ in the center,
	a C terminal E domain and
	a novel domain J domain rich in proline and glutamine between C and E

conjugated

PhosphoP

HOMOLOGY

Homologene

FAMILY

abundant neuron-specific phosphoproteins family

CATEGORY

regulatory , signaling neurotransmitter

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	synaptic vesicles

basic FUNCTION	playing a crucial roles in synaptogenesis and neuronal plasticity
	involved in the regulation of neurotransmitter release

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

synaptic vesicle-associated

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to multiple sclerosis

Variant & Polymorphism SNP	C631/A196 haplotype seemed to confer a significant protection against multiple sclerosis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS