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FLASH GENE
Symbol SYN3 contributors: - updated : 19-10-2005
HGNC name synapsin III
HGNC id 11496
Location 22q12.3      Physical location : 32.908.541 - 33.454.377
DNA
TYPE functioning gene
STRUCTURE 494.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2918 63 581 - Porton
- - 2830 - 439 fetal brain and adult Porton
- - 2626 - 444 brain Porton
- - - - - fetal brain only Porton
- - - - - non neuronal Porton
- - - - - non neuronal Porton
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Nervousbrain    
Reproductivemale systemtestis   
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three conserved domains of the family, the phosphorylated A domain at the N terminus,
  • the large ATP binding, C domain,inhibited by Ca2+ in the center,
  • a C terminal E domain and
  • a novel domain J domain rich in proline and glutamine between C and E
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY abundant neuron-specific phosphoproteins family
    CATEGORY regulatory , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text synaptic vesicles
    basic FUNCTION
  • playing a crucial roles in synaptogenesis and neuronal plasticity
  • involved in the regulation of neurotransmitter release
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein synaptic vesicle-associated
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis
    Variant & Polymorphism SNP C631/A196 haplotype seemed to confer a significant protection against multiple sclerosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS