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FLASH GENE
Symbol SYCP1 contributors: mct - updated : 22-06-2016
HGNC name synaptonemal complex protein 1
HGNC id 11487
Location 1p13.2      Physical location : 115.397.454 - 115.537.988
Synonym name cancer/testis antigen 8
Synonym symbol(s) SCP1, HOM-TES-14, MGC104417, CT8
DNA
TYPE functioning gene
STRUCTURE 140.54 kb     32 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
PHTF1 1p13-p11 putative homeodomain transcription factor 1 FLJ11220 1p13.1 hypothetical protein FLJ11220 PTPN22 1p13.3-p13.1 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) LOC148280 1p13.1 hypothetical LOC148280 AP4B1 1p11.2 adaptor-related protein complex 4, beta 1 subunit DCLRE1B 1p11.2 DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) HIPK1 1p12 DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) HNOEL-iso 1p13.1 HNOEL-iso protein SYT6 1p13.1 synaptotagmin VI MRP63P1 1p13.1 mitochondrial ribosomal protein 63 pseudogene 1 LOC391067 1 LOC391067 TRIM33 1p13.1 tripartite motif-containing 33 LOC347675 1p13.1 eukaryotic translation initiation factor 2 beta-like pseudogene LOC339395 1p13.1 similar to Pyruvate kinase, M2 isozyme BCAS2 1p21-p13.3 breast carcinoma amplified sequence 2 FLJ37099 1p13.1 FLJ37099 protein AMPD1 1p13 adenosine monophosphate deaminase 1 (isoform M) NRAS 1p13.2 neuroblastoma RAS viral (v-ras) oncogene homolog D1S155E 1p22 NRAS-related gene FLJ21168 1p13.1 hypothetical protein FLJ21168 SYCP1 1p13 synaptonemal complex protein 1 TSHB 1p13 thyroid stimulating hormone, beta TSPAN-2 1p13.1 tetraspan 2 NGFB 1p13.1 nerve growth factor, beta polypeptide LOC391068 1 similar to mCAF1 protein VANGL1 1p11-p13.1 vang-like 1 (van gogh, Drosophila) LOC387624 1 hypothetical gene supported by NM_024062 CASQ2 1p13.3-p11 calsequestrin 2 (cardiac muscle) NHLH2 1p12-p11 nescient helix loop helix 2 LOC343019 1p12 similar to Hnrpa1 protein SLC22A15 1p12 solute carrier family 22 (organic cation transporter), member 15
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
32 - 3503 114 976 - 2005 15944401
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal rich in acidic AAs
  • a predicted alpha-helical domain
  • a C terminal domain rich in basic AAs and herboring S/T-P and S/T-S/T involved in DNA binding
  • two potential nuclear localization signals (NLS)
  • a potential p34 cdc2 (CDC2) target site and a leucine zipper
  • HOMOLOGY
    interspecies homolog to murine Scp1
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text in tripartite segments of synaptonemal complexes, between lateral elements in the nucleus
    basic FUNCTION
  • transverse filament protein involved in the structural organization of meiotic prophase chromosomes
  • primary determinant of synaptonemal complexes assembly that plays a key role in synapsis of homologous chromosomes
  • involved with SYCP1 and SYCE2 in synaptonemal complex assembly
  • in addition to their roles as synaptonemal complex components, SYCP1 and SYCP3 act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes
  • CELLULAR PROCESS cell cycle,division,meiosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of synaptonemal complex protein 1, axial element
  • SYCE1 interacts more directly with SYCP1 and could thus anchor the central element proteins to the transverse filaments
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interact with SYCE1, SYCE2, for their localisation to the central element
  • with SCYP2, interact in extracts of meiotic cells
  • interaction with FKBP6 (crucial factor in spermatogenesis because of its interplay with the synaptonemal complex protein SYCP1)
  • PUM1 facilitates the transition of the late meiotic prophase I oocyte from pachytene to diplotene stage by regulating SYCP1 protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS