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FLASH GENE
Symbol SYCP1 contributors: mct - updated : 22-06-2016
HGNC name synaptonemal complex protein 1
HGNC id 11487
Location 1p13.2      Physical location : 115.397.454 - 115.537.988
Synonym name cancer/testis antigen 8
Synonym symbol(s) SCP1, HOM-TES-14, MGC104417, CT8
DNA
TYPE functioning gene
STRUCTURE 140.54 kb     32 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
32 - 3503 114 976 - 2005 15944401
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal rich in acidic AAs
  • a predicted alpha-helical domain
  • a C terminal domain rich in basic AAs and herboring S/T-P and S/T-S/T involved in DNA binding
  • two potential nuclear localization signals (NLS)
  • a potential p34 cdc2 (CDC2) target site and a leucine zipper
  • HOMOLOGY
    interspecies homolog to murine Scp1
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text in tripartite segments of synaptonemal complexes, between lateral elements in the nucleus
    basic FUNCTION
  • transverse filament protein involved in the structural organization of meiotic prophase chromosomes
  • primary determinant of synaptonemal complexes assembly that plays a key role in synapsis of homologous chromosomes
  • involved with SYCP1 and SYCE2 in synaptonemal complex assembly
  • in addition to their roles as synaptonemal complex components, SYCP1 and SYCP3 act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes
  • SYCP1 and SYCE3 form a joint bilayered central structure
  • CELLULAR PROCESS cell cycle,division,meiosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of synaptonemal complex protein 1, axial element
  • SYCE1 interacts more directly with SYCP1 and could thus anchor the central element proteins to the transverse filaments
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interact with SYCE1, SYCE2, for their localisation to the central element
  • with SCYP2, interact in extracts of meiotic cells
  • interaction with FKBP6 (crucial factor in spermatogenesis because of its interplay with the synaptonemal complex protein SYCP1)
  • PLK1, phosphorylates central element proteins SYCP1 and TEX12, and PLK-mediated phosphorylation of central element proteins is required for meiotic prophase exit
  • disruption of SYCE2 and TEX12 (a fourth central element protein) localization to the central element abolishes central alignment of the N-terminal region of SYCP1
  • PUM1 facilitates the transition of the late meiotic prophase I oocyte from pachytene to diplotene stage by regulating SYCP1 protein
  • C1ORF146 interacts with synaptonemal complex protein 1 (SYCP1) and synaptonemal complex central element 3 (SYCE3)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS