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FLASH GENE
Symbol SYCE2 contributors: mct/npt - updated : 12-10-2020
HGNC name synaptonemal complex central element protein 2
HGNC id 27411
Location 19p13.13      Physical location : 13.009.893 - 13.030.086
Synonym name central element synaptonemal complex 1
Synonym symbol(s) CESC1
DNA
TYPE functioning gene
STRUCTURE 21.45 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1248 24.6 218 - 2012 22870393
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
 male systemtestis   
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • SYCE family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus,chromatin/chromosome
    text localisation to the central element in the meiosis
    basic FUNCTION
  • playing a role in synaptonemal-complex assembly, and perhaps also stability and recombination
  • required for synaptonemal complex assembly, double strand break repair, and homologous recombination (Bolcun-Filas 2007)
  • involved with SYCP1 and SYCE1 in synaptonemal complex assembly (Bolcun-Filas 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TEX12 form a complex that interacts with SYCE1 (Hamer 2006)
  • SYCE2-TEX12 complex is an equimolar hetero-octamer, formed from the association of an SYCE2 tetramer and two TEX12 dimers
  • synaptic elongation complex SYCE2–TEX12 is essential for extension of the synaptonemal complex (SC) tripartite structure
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the transverse filament protein SYCP1, and its localisation to the central element appears to depend on recruitment by SYCP1
  • disruption of SYCE2 and TEX12 (a fourth central element protein) localization to the central element abolishes central alignment of the N-terminal region of SYCP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS