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FLASH GENE
Symbol SWI5 contributors: mct - updated : 28-09-2011
HGNC name recombination repair homolog (yeast)
HGNC id 31412
Location 9q34.13      Physical location : -
Synonym name
  • hypothetical protein LOC375757
  • HBV DNAPTP1-transactivated protein A
  • chromosome 9 open reading frame 119
  • DNA repair protein SWI5 homolog
  • Synonym symbol(s) bA395P17.9, c9orf119, RP11-395P17.9
    DNA
    TYPE functioning gene
    STRUCTURE 12.84 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1004 26.6 235 - 2010 20976249
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • SAE3 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • SWI5-SFR1 overcomes, at least partly, the inhibitory effect of RPA, representing a novel class of mediator (
  • SWI5-SFR1 is a newly identified complex required for genomic integrity in mammalian cells with a specific role in the repair of DNA strand breaks
  • SWI5-SFR1 has an evolutionarily conserved function in homologous recombination repair
  • SWI5-SFR1 may potentially play important roles both in mitotic and meiotic homologous recombination reactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SWI5-SFR1 complex plays an important role in homologous recombination
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SFR1 (C-terminal SWI5 domain of SWI5 and the middle coiled-coil region of SFR1 dictate this conserved interaction)
  • SWI5-SFR1 directly interacts with RAD51 and plays a critical role in homologous recombination repair
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS