Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SWAP70 contributors: npt/mct - updated : 03/12/2008
Location 11p15      Physical location : 9.685.627 - 9.774.505
Genatlas name SWAP-70 protein
Synonym name
  • cDNA sequence, expressed in brain, 66kDa, related to Drosophila myosin heavy chain
  • SWAP complex protein 70kDa
  • switch-associated protein 70
  • Synonym symbol(s) KIAA0640, EVI83, HSPC321, FLJ39540
    DNA
    TYPE functioning gene
    STRUCTURE 88.89 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    C11orf17 11p15.3 chromosome 11 open reading frame 17 C11orf16 11p15.3 chromosome 11 open reading frame 16 ASCL3 11p15.3 achaete-scute complex (Drosophila) homolog-like 3 C11orf15 11p15.3 chromosome 11 open reading frame 15 NRIP3 11p15.3 nuclear receptor interacting protein 3 SCUBE2 11p15.3 signal peptide, CUB domain, EGF-like 2 FLJ46111 11p15.3 FLJ46111 protein RAB6IP1 11p15.3 RAB6 interacting protein 1 KIAA0033 11p15.3 KIAA0033 protein IPO7 11p15.3 importin 7 ZNF143 11p15.4-p15.3 zinc finger protein 143 (clone pHZ-1) WEE1 11p15.3 WEE1 homolog (S. pombe) LOC387752 11 similar to 60S ribosomal protein L23a LOC387753 11 similar to 60S ribosomal protein L21 SWAP70 11p15 Homo sapiens SWAP-70 protein (SWAP70), mRNA. CMT4B2 11p15.3 Charcot-Marie-Tooth neuropathy 4B2 (autosomal recessive, with myelin outfolding) ADM 11p15.4 adrenomedullin LOC338749 11p15.3 hypothetical LOC338749 AMPD3 11p15 adenosine monophosphate deaminase (isoform E)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4848 69 585 - Hilpela (2003)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    Respiratoryrespiratory tractlarynx  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three nuclear localization signals (NLS)
  • HOMOLOGY
    interspecies homolog to Drosophila myosin heavy chain
    Homologene
    FAMILY
  • pleckstrin-like family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • acting as a link between the recognition of specific switch regions and causation of a DNA break
  • multiple functional signaling protein involved in formation of membrane ruffling induced by signal cascade of tyrosine kinase growth factor receptors
  • may be involved in regulating migration and invasion of trophoblast cells during the processes of embryonic implantation and placentation
  • regulates the actin cytoskeleton as an effector or adaptor protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion
  • F-actin-binding, Rho GTPase-interacting protein strongly expressed in activated B cells, that is necessary for normal B-cell migration
  • regulates integrin-mediated adhesion and cell attachment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of an enzyme complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binds to F-actin
  • cooperates with Rac
  • binding activity of SWAP70 to non-muscle F-actin is required for membrane ruffling
  • important target of SYK in migration and polarization of naive recirculating B cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS