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FLASH GENE
Symbol SVEP1 contributors: mct - updated : 22-08-2013
HGNC name sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
HGNC id
Location 9q31.3      Physical location : 113.127.530 - 113.342.160
Synonym name
  • CCP module-containing protein 22
  • selectin-like osteoblast-derived protein
  • selectin-like protein
  • serologically defined breast cancer antigen NY-BR-38
    • Synonym symbol(s) C9orf13, CCP22, POLYDOM, SEL-OB, SELOB
    DNA
    TYPE functioning gene
    STRUCTURE 214.63 kb     48 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • putative promoter of SVEP1 can be hypermethylated, thus regulating SVEP1 expression levels (PMID
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text existence of an alternative promoter (AP) (PMID: 22659106)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    48 - 12356 370 3571 - 2012 22659106
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skeleton      Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple domains including complement control protein (CCP) modules with selectin superfamily signature; sushi and other domains, such as vWA, EGF, PTX, and HYR
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • expressed during early phases of myogenic differentiation through the initial stage of myoblast fusion and myotube formation
  • multi-domain protein recognized as a cell adhesion molecule (CAM)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SVEP1 and SRPX2 seemed to act as regulators of ICAM1 and E-selectin shedding and influence the expression of membrane bound adhesion molecules
  • hitherto unknown ligand for integrin alpha9beta1 that functions as a physiological ligand
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a useful biomarker for studying the mechanism of cells interactions within the local microenvironment affected by estrogen
  • potential biomarker for pre-fated satellite cells
    • Therapy target
    ANIMAL & CELL MODELS