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FLASH GENE
Symbol SV2B contributors: mlc - updated : 20-11-2007
HGNC name synaptic vesicle glycoprotein 2B
HGNC id 16874
Location 15q26.1      Physical location : 91.643.181 - 91.844.538
Synonym symbol(s) KIAA0735
DNA
TYPE functioning gene
STRUCTURE 69.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 5311 - 683 - Lazzell (2004)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Endocrinepancreas   lowly
Nervousbrain   moderately
 brainforebraincerebral cortex predominantly
 braindiencephalonhypothalamus predominantly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to Drosophila CG3168
intraspecies homolog to SV2A (65 p100)
Homologene
FAMILY
CATEGORY secretory , transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic,vesicle
text synaptic vesicle
basic FUNCTION
  • mediating the uptake of neurotransmitters into vesicles (required a proton gradient)
  • involved in the regulation of synaptic vesicle exocytosis
  • playing a specific role in the regulation of synaptotagmin 1 levels at certain synapses
  • acting as a regulator of synaptotagmin 1 that is likely mediated by direct interaction of these two synaptic proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system , exocytosis transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component SV2B-synaptotagmin 1 complex also contained the synaptic t-SNARE proteins, syntaxin 1 and SNAP-25, suggesting that SV2B may participate in exocytosis by modulating the interaction of synaptotagmin 1 with t-SNARE proteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts strongly with synaptotagmin 1 in a detergent-resistant, Ca2+ -independent manner
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS