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FLASH GENE
Symbol SV2A contributors: mlc - updated : 20-11-2007
HGNC name synaptic vesicle glycoprotein 2A
HGNC id 20566
Location 1q21.2      Physical location : 149.874.875 - 149.889.434
Synonym symbol(s) SV2, KIAA0736
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     13 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391095 1 similar to hypothetical protein MGC8902 KIAA0493 1q21.3 KIAA0493 protein LOC388692 1 hypothetical gene supported by AK123662 LOC199882 1q21.3 similar to KIAA0454 protein FCGR1A 1q21.2-q21.3 Fc fragment of IgG, high affinity Ia, receptor for (CD64) HIST2H2BA 1 histone 2, H2ba LOC391096 1 similar to CG31613-PA HIST2H4 1q21 histone 2, H4 HIST2H3A 1 histone 2, H3a HIST2H2AA 1q21 histone 2, H2aa LOC388693 1 hypothetical gene supported by BC005827; NM_003528 HIST2H2BC 1 histone 2, H2bc LOC391097 1 similar to histone protein Hist2h3c1 HIST2H2BE 1q21-q23 histone 2, H2be HIST2H2AC 1q21 histone 2, H2ac HIST2H2AB 1q21 histone 2, H2ab CGI-143 1p36.13-q31.3 CGI-143 protein SV2A 1q21.2 synaptic vesicle glycoprotein 2A SF3B4 1p22.1-p21.3 splicing factor 3b, subunit 4, 49kDa CRA 1q12-q21 cisplatin resistance associated ZA20D1 1q21.3 zinc finger, A20 domain containing 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 4066 - 742 - Gregory (2006)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestivesalivary gland   highly
Nervousbrain   predominantly
Reproductivefemale systemovary  highly
 male systemtestis  highly
Respiratorylung   highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
twelve transmembrane domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to Drosophila CG3168
Homologene
FAMILY
CATEGORY secretory , transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
intracellular,cytoplasm,cytosolic,vesicle
text synaptic vesicle
basic FUNCTION synaptic vesicle transmembrane proteoglycan, involved in the control of exocytosis
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS nervous system , exocytosis transport
PATHWAY
metabolism
signaling neurotransmission
a component
INTERACTION
DNA
RNA
small molecule
protein interaction between purified SV2 and laminin-1, a laminin isoform with a similar structure
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS