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FLASH GENE
Symbol SUV39H2 contributors: mct/npt - updated : 22/09/2008
HGNC name suppressor of variegation 3-9 homolog 2 (Drosophila)
HGNC id 17287
Location 10p13      Physical location : 14.920.781 - 14.946.302
Synonym name
  • histone-lysine N-methyltransferase
  • H3 lysine-9 specific 2
  • H3-K9-HMTase 2
  • Synonym symbol(s) FLJ23414, KMT1B
    EC.number 2.1.1.43
    DNA
    TYPE functioning gene
    STRUCTURE 25.42 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389939 10 similar to ribosomal protein L5 OPTN 10p14 optineurin MCM10 10p13 MCM10 minichromosome maintenance deficient 10 (S. cerevisiae) LOC221044 10p14 hypothetical protein BC018068 PHYH 10p15-p14 phytanoyl-CoA hydroxylase (Refsum disease) SEPHS1 10p14 selenophosphate synthetase 1 C10orf30 10p14 chromosome 10 open reading frame 30 PRPF18 10p12.33 PRP18 pre-mRNA processing factor 18 homolog (yeast) FLJ10210 C10orf45 10p14 chromosome 10 open reading frame 45 LOC283071 10p14 similar to hypothetical protein 9330140G23 HSP70-4 10p14 likely ortholog of mouse heat shock protein, 70 kDa 4 SUV39H2 10p13 suppressor of variegation 3-9 homolog 2 (Drosophila) DCLRE1C 10p14-p13 DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) LOC389940 10 similar to seven transmembrane helix receptor FLJ11106 10p13 hypothetical protein FLJ11106 LOC387634 10 similar to Acyl-CoA-binding protein (ACBP) (Diazepam binding inhibitor) (DBI) (Endozepine) (EP) MGC35468 10p13 hypothetical protein MGC35468 RPP38 10p13 ribonuclease P (38kD) NMT2 10p12.33-p12.32 N-myristoyltransferase 2 LOC221061 10p13 hypothetical protein LOC221061 ITGA8 10p13 integrin, alpha 8 FLJ13397 10p13 hypothetical protein FLJ13397 PTER 10p12 phosphotriesterase related LOC389941 10 similar to Gliacolin RSU1 10p13 Ras suppressor protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3093 - 350 - Frontelo (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one CHROMO domain
  • one post-SET domain
  • one pre-SET domain
  • one SET domain
  • HOMOLOGY
    interspecies ortholog to murine Suv39h2
    ortholog to rattus Suv39h2_predicted
    homolog to dog LOC477995
    Homologene
    FAMILY
  • histone-lysine methyltransferase family
  • suvar3-9 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    basic FUNCTION
  • histone-lysine N-methyltransferase activity, playing a role in protecting the genome stability
  • chromatin modifier enzyme that cooperate in BMP-induced repression
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA chromatin binding
    RNA
    small molecule metal binding,
  • ion Zn2+ binding
  • protein
  • interaction with SMAD5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    at specific stages of spermatogenesis, suggesting that they play an important role in the epigenetic reprogramming during spermatogenesis (Wawrzik 2009)
    Susceptibility to lung cancer for the smokers
    Variant & Polymorphism other polymorphism may be an important predictive marker for lung cancer susceptibility for the smokers
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice double-null (Suv39h1 -/-, Suv39h2 -/-) have an increased tumor risk and perturbed chromosome interaction during male meiosis