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FLASH GENE
Symbol SUV39H2 contributors: mct/npt - updated : 15-10-2019
HGNC name suppressor of variegation 3-9 homolog 2 (Drosophila)
HGNC id 17287
Location 10p13      Physical location : 14.920.781 - 14.946.302
Synonym name
  • histone-lysine N-methyltransferase
  • H3 lysine-9 specific 2
  • H3-K9-HMTase 2
  • Synonym symbol(s) FLJ23414, KMT1B
    EC.number 2.1.1.43
    DNA
    TYPE functioning gene
    STRUCTURE 25.42 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3093 - 350 - Frontelo (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one CHROMO domain
  • one post-SET domain
  • one pre-SET domain
  • one SET domain
  • HOMOLOGY
    interspecies ortholog to murine Suv39h2
    ortholog to rattus Suv39h2_predicted
    homolog to dog LOC477995
    Homologene
    FAMILY
  • histone-lysine methyltransferase family
  • suvar3-9 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    basic FUNCTION
  • histone-lysine N-methyltransferase activity, playing a role in protecting the genome stability
  • chromatin modifier enzyme that cooperate in BMP-induced repression
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA chromatin binding
    RNA
    small molecule metal binding,
  • ion Zn2+ binding
  • protein
  • interaction with SMAD5
  • in human fetal lung epithelial cells, SUV39H1 and SUV39H2 mRNA levels declined with cAMP induction of SFTPA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    at specific stages of spermatogenesis, suggesting that they play an important role in the epigenetic reprogramming during spermatogenesis (Wawrzik 2009)
    Susceptibility to lung cancer for the smokers
    Variant & Polymorphism other polymorphism may be an important predictive marker for lung cancer susceptibility for the smokers
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice double-null (Suv39h1 -/-, Suv39h2 -/-) have an increased tumor risk and perturbed chromosome interaction during male meiosis