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FLASH GENE
Symbol SUV39H1 contributors: mct - updated : 30-11-2015
HGNC name suppressor of variegation 3-9 homolog 1 (Drosophila)
HGNC id 11479
Location Xp11.23      Physical location : 48.555.130 - 48.567.404
Synonym name
  • H3-K9-HMTase 1
  • Su(var)3-9 homolog 1
  • histone H3-K9 methyltransferase
  • Synonym symbol(s) SUV39H, MG44
    EC.number 2.1.1.43
    DNA
    TYPE functioning gene
    STRUCTURE 12.28 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure binding sites for GAGA and ADF1 transcription factor
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2745 - 412 - 2011 21504832
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     mouth   highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text mesoderm derived somites, liver, heart, stomach
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal chromatin organization modifier domain (chromo)
  • cysteine rich region, putative nuclear localization signal (NLS)
  • C termianl SET domain (Su-Var 3-9, enhancer of zeste, thithorax)
  • HOMOLOGY
    interspecies homolog to Drosophila Su(Var) 3-9
    Homologene
    FAMILY Su-Var family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • major enzymes that implement chromatin structural changes through histone modifications during the formation of heterochromatin
  • increased CABIN1-mediated repression of MEF2 transcriptional activity in MEF2-targeting promoters
  • represses MyoD-stimulated myogenic differentiation
  • potentially affects promoters activity in two different pathways, by association with histone deacetylases and by recruiting chromatin-modifying enzymes to impose a heterochromatin-like structure establishing a lasting transcription repression
  • SUV39H1-independent association of CBX1 with fibrillarin-positive nucleolar regions
  • SUV39H1 and LMNA likely play a key role in telomere maintenance and telomere nuclear architecture
  • stabilization of SUV39H1 by SIRT1 is part of oxidative stress response and ensures genome protection
  • RRP8 is a nucleolar protein, important for mediating the assembly of the energy-dependent nucleolar silencing complex (eNoSC), which also contains SIRT1 and SUV39H1
  • CELLULAR PROCESS nucleotide, chromatin organization
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding on the MEF2 target promoter in a calcium-dependent manner
    RNA
    small molecule
    protein
  • CBX1
  • binding to the 501-900-amino acid region of CABIN1
  • interacting with SIRT1 (functional link between the heterochromatin-related histone methyltransferase SUV39H1 and the histone deacetylase SIRT1)
  • interacting with ESCO2
  • EVI1 directly interacts with SUV39H1 and the proteins form an active complex with methyltransferase activity
  • KIAA1967 binds to the SUV39H1 catalytic domain and inhibits its ability to methylate histone H3
  • interaction with BCL11B (constitutive CDKN1A gene suppressor that cooperates with SUV39H1 and histone methylation to silence the CDKN1A gene transcription)
  • targeted to TP53 target promoters by binding MDM2 acidic domain and neutralizing its TP53 conformational effect, forming a TP53-MDM2-SUV39H1 complex capable of DNA binding and transcription repression
  • interaction with SIRT1 (SIRT1 controls global levels of SUV39H1 by increasing its half-life through inhibition of SUV39H1 lysine 87 polyubiquitination by the E3-ubiquitin ligase MDM2)
  • UHRF1 might interact with SUV39H1 and, through this interaction, direct the recruitment of SUV39H1 to gene promoters
  • KLF11 recruits CBX5 and its histone methyltransferase, SUV39H1, to promoters to limit KLF11-mediated gene activation
  • MECOM and PRDM16 initiate heterochromatin formation by inducing cytoplasmic H3K9me1, which is then converted in the nucleus by the SUV39H1 enzymes to H3K9me3
  • specific role for CBX1, CBX3, CBX5 in regulating SUV39H1 function under stress via a feedback mechanism that likely regulates heterochromatin formation
  • cell & other
    REGULATION
    activated by stress conditions that lead to SIRT1 upregulation, such as calorie restriction, also induce higher levels of SUV39H1 in a SIRT1-dependent manner
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS