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FLASH GENE
Symbol SURF4 contributors: mct - updated : 21-06-2017
HGNC name surfeit 4
HGNC id 11476
Location 9q34.2      Physical location : 136.228.340 - 136.242.970
Synonym name
  • surfeit locus protein 4
  • surface 4 integral membrane protein
    • Synonym symbol(s) ERV29, FLJ22993, MGC102753, SURF-4
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 16.50 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see SURF@
    regionally located mapped to the telomeric end of the surfeit cluster
    RNA
    TRANSCRIPTS type messenger
    text transcript length variation resulting from the use of multiple polyadenylation sites
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 3068 30.4 269 - 2008 18287528
    6 splicing 2923 - 254 - 2008 18287528
    6 - 2709 - 159 - 2008 18287528
    5 - 2881 - 128 - 2008 18287528
    5 - 2991 - 152 - 2008 18287528
    7 - 3218 - 226 - 2008 18287528
    6 - 3166 - 226 - 2008 18287528
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments
  • a predicted lumenal N terminus
  • multiple phosphorylation sites and a double-lysine retrieval motif at the C terminus
    • HOMOLOGY
    interspecies ortholog to murine Surf4
    homolog to Drosophila Surf4
    ortholog to yeast cargo receptor Erv29p
    Homologene
    FAMILY
  • SURF4 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • SURF4 associated with STIM1 in the endoplasmic reticulum
    • basic FUNCTION
  • may be required for packaging glycosylated pro-alpha-factor into COPII vesicles
  • modulatory function of SURF4 for STIM1-mediated Store-operated Ca(2+) entry
  • SURF4 modulate STIM1 puncta formation and/or relocation to the ER–Plasma membrane (PM) junctions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SURF4 associated with STIM1 in the endoplasmic reticulum, and is a STIM1 binding partner
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS