protein
| interaction with SSPN (recruited via interaction with RNAPII, and SSPN is necessary for SUPT6H recruitment) (Zhang 2008) |
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binds Ser2-phosphorylated (Ser2P) RNA polymerase II (RNAPII) through a primitive SH2 domain, which recognizes phosphoserine rather than phosphotyrosine residues (Yoh 2007) |
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IWS1 is SUPT6H-interacting protein (Yoh 2007) |
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KDM6B and KDM7A play a role in localizing elongation factors SUPT6H and SUPT16H to the target genes |
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SUPT6H regulates both class-switch recombination (CSR) and somatic hypermutation through H3K4me3 marks on AICDA target loci |
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SUPT6H is a unique histone chaperone capable of regulating the histone epigenetic state of both AICDA targets and the AICDA locus |
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through cooperation with POLR2A and KDM6A, SUPT6H orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation |
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is required for estrogen-regulated transcription and the maintenance of chromatin structure in breast cancer cells, possibly in part through interaction with RNF40 |
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is a new epigenetic regulator of ESR1 activity and cellular differentiation |
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SUPT6H recruitment is abrogated in cells lacking the histone methyltransferase NSD2 |
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