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FLASH GENE
Symbol SUPT6H contributors: mct/npt - updated : 22-02-2017
HGNC name suppressor of Ty 6 homolog (S. cerevisiae)
HGNC id 11470
Location 17q11.2      Physical location : 26.989.301 - 27.029.248
Synonym name
  • Emb5 protein
  • suppressor of Ty (S.cerevisiae) 6 homolog
  • Tat-cotransactivator 2 protein
  • Tat-CT2 protein
  • Synonym symbol(s) SPT6, KIAA0162, SPT6H, emb-5, MGC87943,
    DNA
    TYPE functioning gene
    STRUCTURE 40.50 kb     37 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    regionally located tighly linked to WHN
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    37 - 5896 - 1726 - 2013 23503590
    38 - 6534 - 1726 - 2013 23503590
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     pharynx   highly
    Urinarykidney   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • SH2 domain and a leucine zipper
  • HOMOLOGY
    interspecies homolog to yeast spt6 (suppressor of Ty)
    Homologene
    FAMILY
  • emb-5 transcription initiation factor STP6 family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • putative chromatin structure regulator
  • may be a mediator of differentiation and development through the establishment and/or maintenance of
  • chromatin structure
  • promotes transcription elongation at many genes and functions as a histone H3 chaperone to alter chromatin structure during transcription (Yoh 2007)
  • significantly precedes Swi/Snf occupancy at the promoter and in absence of SSPN recruitment, Swi/Snf is constitutively found at the promoter (Zhang 2008)
  • participating in the regulation of transcription by RNA polymerase II (RNAPII)
  • is involved in differential regulation of class switch recombination (CSR) and somatic hypermutation (SHM) by AICDA
  • cellular protein SUPT6H is required for efficient replication of human cytomegalovirus
  • is a unique histone chaperone capable of regulating the histone epigenetic state of both activation-induced cytidine deaminase (AID) targets and the AID locus
  • regulates class-switch recombination (CSR) through H3K4me3 modification of the target chromatin
  • regulates transcription and DNA breakage
  • is a histone chaperone that links transcriptional elongation to changes in chromatin structure
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • IWS1 connects two distinct C-terminal domain-binding proteins, SUPT6H and SETD2, in a megacomplex that affects mRNA export as well as the histone modification state of active genes (Yoh 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with SSPN (recruited via interaction with RNAPII, and SSPN is necessary for SUPT6H recruitment) (Zhang 2008)
  • binds Ser2-phosphorylated (Ser2P) RNA polymerase II (RNAPII) through a primitive SH2 domain, which recognizes phosphoserine rather than phosphotyrosine residues (Yoh 2007)
  • IWS1 is SUPT6H-interacting protein (Yoh 2007)
  • KDM6B and KDM7A play a role in localizing elongation factors SUPT6H and SUPT16H to the target genes
  • SUPT6H regulates both class-switch recombination (CSR) and somatic hypermutation through H3K4me3 marks on AICDA target loci
  • SUPT6H is a unique histone chaperone capable of regulating the histone epigenetic state of both AICDA targets and the AICDA locus
  • through cooperation with POLR2A and KDM6A, SUPT6H orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation
  • is required for estrogen-regulated transcription and the maintenance of chromatin structure in breast cancer cells, possibly in part through interaction with RNF40
  • is a new epigenetic regulator of ESR1 activity and cellular differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS