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FLASH GENE
Symbol SUPT5H contributors: mct - updated : 09-10-2013
HGNC name suppressor of Ty 5 homolog (S. cerevisiae)
HGNC id 11469
Location 19q13.2      Physical location : 39.936.185 - 39.967.306
Synonym name Foggy
Synonym symbol(s) SPT5, SPT5H
DNA
TYPE functioning gene
STRUCTURE 31.12 kb     29 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map cen - RYR1 - CLC - SUPT5H - AKT2 - qter
Authors Chiang (96)
Physical map
MRPS12 19q13.11 mitochondrial ribosomal protein S12 FBXO26 19q13.2 F-box only protein 26 FBXO27 19q13.2 F-box only protein 27 LOC390928 19 similar to RIKEN cDNA C330005M16 LOC284321 19q13.2 hypothetical LOC284321 PAK4 19q13.2 p21(CDKN1A)-activated kinase 4 LOC342897 19q13.2 similar to F-box only protein 2 SYCN 19q13.2 syncollin IL28B 19q13.13 interleukin 28B (interferon, lambda 3) LOC390929 19 similar to Methionine-R-sulfoxide reductase (Selenoprotein X 1) (HSPC270) IL28A 19q13.13 interleukin 28A (interferon, lambda 2) IL29 19q13.13 interleukin 29 (interferon, lambda 1) KIAA1484 GMFG 19p13.2-p12 glia maturation factor, gamma FLJ10211 19q13.2 hypothetical protein FLJ10211 PD2 19q13.1 hypothetical protein F23149_1 Intersex 19q13.2 homolog of Drosophila Intersex ZFP36 19q13.1 zinc finger protein 36, C3H type, homolog (mouse) CLG 19q13.2 likely ortholog of mouse common-site lymphoma/leukemia GEF RPS16 19q13.1 ribosomal protein S16 SUPT5H 19q13 suppressor of Ty 5 homolog (S. cerevisiae) TIMM50 19q13.2 translocase of inner mitochondrial membrane 50 homolog (yeast) DLL3 19q13.1-13.3 delta-like 3 (Drosophila) SELV 19q13.2 selenoprotein V FLJ38944 19q13.2 hypothetical protein FLJ38944 MGC20452 LOC390930 19 similar to Charot-Leyden crystal protein; Charcot-Leyden crystal protein; eosinophil lysophospholipase; lysolecithin acylhydrolase; galactin-10 PP13 19q13.1 placental protein 13 LOC390931 19 similar to placental protein 13-like protein LOC148003 19q13.2 similar to placental protein 13; galectin-13 LOC390932 19 similar to Eosinophil lysophospholipase (Charcot-Leyden crystal protein homolog) (Lysolecithin acylhydrolase) (CLC) (Galectin-10) PPL13 19q13.2 placental protein 13-like protein CLC 19q13.1 Charot-Leyden crystal protein LOC342900 19q13.2 hypothetical LOC342900 DYRK1B 19q12-q13.11 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B FBL 19q13.1 fibrillarin FCGBP 19q13.1 Fc fragment of IgG binding protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
30 - 3734 - 1087 - 2010 19860741
29 - 3722 - 1083 - 2010 19860741
30 - 3659 - 1087 - 2010 19860741
29 - 3798 - 1087 - 2010 19860741
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Nervousbrain   highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a very acidic 5'domain, and seven MAP kinase sites
  • two repeat-containing regions (CTR1 and CTR2CT) constituting the C-terminus of SUPT5H, play a redundant role in repressing RNAPII elongation, and C-terminus is critical for repressing RNAPII elongation ; modification of the CTR is crucial for recruitment of PAF1 to active genes
  • HOMOLOGY
    interspecies homolog to yeast Spt5 (histones group)
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • putative chromatin structure regulator
  • regulating mRNA processing and transcription elongation by RNA polymerase II
  • acting cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter
  • plays an important role in GATA1 gene expression and erythropoiesis through its transcriptional activation domain
  • SUPT4H1, SUPT5H can function independently in multiple transcription-coupled steps of class-switch recombination (CSR)
  • eukaryotic SUPT4H1-SUPT5H complex appears to couple chromatin modification states and RNA processing to transcription elongation
  • SUPT4H1-SUPT5H plays an important role in the recruitment of transcription elongation and RNA-processing factors to RNA pol II
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the DRB sensitivity-inducing factor complex (DSIF complex)
  • DSIF is composed of the two subunits, SUPT4H1 and SUPT5H
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDK7 thus acts through GTF2E1, GTF2E2 and SUPT5H to establish, and through CDK9 to relieve, barriers to elongation
  • MCM3AP interacts with the transcription stalling protein SUPT5H and facilitates RNA Pol-II recruitment to immunoglobulin variable regions
  • SUPT5H binding is mediated by an extended surface containing phosphothreonine recognition and hydrophobic interfaces that interact with AAs outside the SPT5H motif
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS