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FLASH GENE
Symbol SUPT4H1 contributors: mct - updated : 09-10-2013
HGNC name suppressor of Ty 4 homolog 1 (S. cerevisiae)
HGNC id 11467
Location 17q22      Physical location : 56.422.538 - 56.429.563
Synonym symbol(s) SPT4H, SUPT4H, EVI159, SPT4
DNA
TYPE functioning gene
STRUCTURE 7.06 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
MRPS23 17q22-q23 mitochondrial ribosomal protein S23 C14orf34 14q23.2 chromosome 14 open reading frame 34 ZNF161 17q23.3 zinc finger protein 161 SFRS1 17q21.3-q22 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) Dlc2 17q23.2 dynein light chain 2 OR4D1 17q24.2 olfactory receptor, family 4, subfamily D, member 1 HSHPX5 17q23.2 HPX-5 LOC124538 17q23.2 similar to Olfactory receptor 4D2 EPX 17q24-q25 eosinophil peroxidase FLJ20345 17q23.2 hypothetical protein FLJ20345 LPO 17q23.1 lactoperoxidase MPO 17q22-q23.1 myeloperoxidase BZRAP1 17q22-q23 benzodiazapine receptor (peripheral) associated protein 1 SUPT4H1 17q21-q23 suppressor of Ty 4 homolog 1 (S. cerevisiae) FLJ20315 17q23.2 hypothetical protein FLJ20315 FLJ40311 17q23.2 hypothetical protein FLJ40311 MTMR4 1721.1-q23 myotubularin related protein 4 PNUTL2 17q22-q23 peanut-like 2 (Drosophila) FLJ40121 17q23.2 hypothetical protein FLJ40121 TEX14 17q22-q23 testis expressed sequence 14 RAD51C 17q22-q23 RAD51 homolog C (S. cerevisiae) PPM1E 17q23.2 protein phosphatase 1E (PP2C domain containing) TRIM37 17q22-q23 tripartite motif-containing 37 LOC348235 17q23.2 hypothetical protein LOC348235
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1545 14 117 - 2012 22341442
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivesalivary gland   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal zinc-finger domain that at least in yeast is essential for biochemical activity
  • HOMOLOGY
    interspecies homolog to yeast spt4 (suppressor of Ty)
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • putative chromatin structure regulator
  • may be involved in mRNA capping, homologous DNA recombination, and transcription-coupled DNA repair
  • can aid RNA polymerase II processivity by reducing dissociation of polymerase from the template
  • exert its role in transcriptional regulation, and possibly in other nuclear processes, as parts of the DSIF complex
  • is selectively required for transcription through extended trinucleotide repeats
  • is required for the transcriptional machinery to proceed through a long expansion of the CAG repeat sequence, but is dispensable for transcription of a region containing a short stretch of CAG repeats
  • SUPT4H1, SUPT5H can function independently in multiple transcription-coupled steps of class-switch recombination (CSR)
  • eukaryotic SUPT4H1-SUPT5H complex appears to couple chromatin modification states and RNA processing to transcription elongation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component SUPT4H1/SUPT5H complex, termed DRB-sensitivity inducing factor (DSIF) is a dual regulator of transcription that stimulates, or, when cooperating with negative elongation factor (NELF), represses RNA polymerase II (RNAPII) elongation
  • DSIF is composed of the two subunits, SUPT4H1 and SUPT5H
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS