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FLASH GENE
Symbol SUPT3H contributors: npt/ - updated : 10-03-2007
HGNC name suppressor of Ty 3 homolog (S. cerevisiae)
HGNC id 11466
Location 6p21.1      Physical location : 44.796.471 - 45.345.670
Synonym name SPT3-like protein
Synonym symbol(s) RP11-169I2.1, SPT3, SPT3L
DNA
TYPE functioning gene
STRUCTURE 549.20 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CAPN11 6p12 calpain 11 LOC389393 6 LOC389393 SLC29A1 6p21.2-p21.1 solute carrier family 29 (nucleoside transporters), member 1 HSPCB 6p12 heat shock 90kDa protein 1, beta SLC35B2 6p12.1-p11.2 solute carrier family 35, member B2 NFKBIE 6p21.1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon LOC391922 6 similar to hypothetical protein MGC33486 MGC33600 6p21.1 hypothetical protein MGC33600 AARSL 6p21.1 alanyl-tRNA synthetase like SPATS1 6p21.1 spermatogenesis associated, serine-rich 1 CDC5L 6p21 CDC5 cell division cycle 5-like (S. pombe) SUPT3H 6p21.3-p21.1 suppressor of Ty 3 homolog (S. cerevisiae) RUNX2 6p21 runt-related transcription factor 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1164 - 317 - Liu (2003)
13 - 2500 - 328 - Liu (2003)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 thyroid   highly
Nervousnervecranial nerve  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast spt3 (suppressor of Ty)
Homologene
FAMILY
CATEGORY regulatory , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • putative chromatin structure regulator
  • probable transcriptional activator
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the PCAF complex
  • component of the mammalian STAGA (SUPT3H-TAF9-TADA1-KAT2A-SUPT7H acetyltransferase) a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors (Martinez 2001)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATXN7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS