Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SUN5 contributors: mct - updated : 23-11-2016
HGNC name Sad1 and UNC84 domain containing 5
HGNC id 16252
Corresponding disease
SPGF16 spermatogenic failure-16
Location 20q11.21      Physical location : 31.571.581 - 31.592.239
Synonym name
  • sperm associated antigen 4-like
  • testis and spermatogenesis related gene 4
  • SUN domain-containing protein 5
  • Synonym symbol(s) TSARG4, dJ726C3.1, SPAG4L, MGC33594
    DNA
    TYPE functioning gene
    STRUCTURE 20.66 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1267 43.08 379 - 2003 12621555
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell Homo sapiens
    Reproductivespermatid Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Sad1 and UNC84 domain
  • a conserved SUN domain in the C-terminal
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope,int
    text restricted to the apical nuclear region of round spermatids that face the acrosomic vesicle
  • is localized to the NE and the endoplasmic reticulum (ER)
  • nuclear membrane protein connecting the coupling apparatus to the sperm nuclear envelope
  • basic FUNCTION
  • involved in linkage of the acrosomic vesicle to the spermatid nucleus, and in acrosome biogenesis
  • integral proteins of the inner nuclear membrane that functions in linkage of the nuclear lamina to the cytoskeleton
  • may be involved in nuclear envelope (NE) reconstitution and nuclear migration occurring during the process of spermatocyte division
  • new NE protein, that may play an important role in the meiotic stage of spermatogenesis
  • serve to link the nuclear envelope to the cytoskeleton
  • is not, as initially reported, facing the acrosome but is in fact excluded from this zone
  • PMFBP1 and SUN5 might work in a similar way to maintain sperm head and tail integrity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PMFBP1 cooperates with SUN5 and SPATA6 to connect sperm head to tail
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF16
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS