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FLASH GENE
Symbol SULT1C2 contributors: - updated : 23-07-2007
HGNC name sulfotransferase family, cytosolic, 1C, member 2
HGNC id 11456
Location 2q11.1-q11.2      Physical location : 108.905.094 - 108.926.370
Synonym name
  • sulfotransferase family, cytosolic, 1C, member 1
  • sulfotransferase 1C1
  • Synonym symbol(s) SULT1C, ST1C1, SULT1C1, ST1C2, humSULTC2
    EC.number 2.8.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 21.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2799 34 296 - Freimuth
    - - 2832 - 307 - Freimuth
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     salivary gland   highly
    Endocrineparathyroid   highly
    Nervousspinal cord   lowly
    Reproductivefemale systemovary  lowly
     male systemprostate   
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in lung and kidney and lowly in heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    sulfotransferase domain
    HOMOLOGY
    interspecies homolog to Drosophila CG5428
    homolog to C.elegans T15D6.1
    Homologene
    FAMILY sulfotransferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • transfer the sulpho moiety from the cofactor 5'-phosphoadenosine-3'-phosphosulphate (PAPS) to nucleophilic groups of xenobiotics and small endogenous compounds (such as hormones and neurotransmitters)
  • involved in the activation of carcinogenic hydroxylamines
  • catalyzing the sulfate conjugation of many drugs, xenobiotic compounds, hormones and neurotransmitters
  • involved in biotransformation of endogenous and exogenous substrates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS