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FLASH GENE
Symbol SULT1A1 contributors: npt/ - updated : 11-01-2006
HGNC name sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
HGNC id 11453
Location 16p11.2      Physical location : 28.616.917 - 28.634.866
Synonym name
  • thermostable phenol sulfotransferase
  • phenol-sulfating phenol sulfotransferase
  • phenol-preferring phenol sulfotransferase1
  • Synonym symbol(s) HAST1, P-PST, STIA3, STP, TS-PST, STP1, SUP1, HAST1/HAST2, PST, MGC5163, MGC131921, ST1A1
    EC.number 2.8.2.1
    DNA
    TYPE functioning gene
    STRUCTURE 17.95 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1222 - 295 - -
    8 - 1253 - 295 - -
    8 - 1399 - 295 - -
    7 - 1598 - 295 - -
    6 - 1239 - 217 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinethyroid   highly
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectivebone  highly
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines osteosarcoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the LDQKW sequence motif
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Sult1a1
    Homologene
    FAMILY
  • sulfotransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • aryl (phenol) sulfotransferase 1, phenol preferring, catalyzing the sulphonation of dopamine and p-nitrophenol
  • catalyzes the sulfate conjugation of a wide variety of natural and synthetic compounds
  • drug and hormone metabolizing enzyme having a potential role as a risk factor for disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in myeloma
    Susceptibility to endometrial cancer in Caucasians
    Variant & Polymorphism SNP single nucleotide polymorphism may be risk factors for endometrial cancer in Caucasians (Hirata 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS