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FLASH GENE
Symbol SULF2 contributors: mct/npt - updated : 30-05-2017
HGNC name sulfatase 2
HGNC id 20392
Location 20q13.12      Physical location : 46.286.150 - 46.415.360
Synonym name
  • N-acetylglucosamine 6 sulfatase precursor homolog
  • sulfatase 2
  • homo sapiens similar to glucosamine-6-sulfatases (SULF2), mRNA
  • extracellular sulfatase SULF-2
  • Synonym symbol(s) HSULF-2, KIAA1247, DKFZp313E091, FLJ90554, MGC126411
    EC.number 3.1.6.-
    DNA
    TYPE functioning gene
    STRUCTURE 132.05 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CDH22 20q12-q13.1 cadherin-like 22 SLC35C2 20q13.12 solute carrier family 35, member C2 ELMO2 20q13 engulfment and cell motility 2 (ced-12 homolog, C. elegans) DKFZp547G0215 20q13.12 hypothetical protein DKFZp547G0215 MKRNP3 20q21.1 makorin, ring finger protein, pseudogene 3 LOC343593 20q13.12 similar to BC331191_1 ZNF334 20q13.12 zinc finger protein 334 SLC13A3 20q12-q13.1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 C20orf64 20q13 chromosome 20 open reading frame 64 SLC2A10 20q13.1 solute carrier family 2 (facilitated glucose transporter), member 10 EYA2 20q13.1 eyes absent homolog 2 (Drosophila) PRKCBP1 20q12-q13.1 protein kinase C binding protein 1 RPL35AP 20q12-q13.1 ribosomal protein L35a pseudogene NCOA3 20q12 nuclear receptor coactivator 3 SULF2 20q12-q13.1 Homo sapiens similar to glucosamine-6-sulfatases (SULF2), mRNA. SRMP1 20q13.13 spermidine synthase pseudogene 1 LOC388798 20 LOC388798 PREX1 20q12-q13 LOC388798 ARFGEF2 20q13.13 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) SNAP23P 20 synaptosomal-associated protein, 23kDa pseudogene CSE1L 20q13 CSE1 chromosome segregation 1-like (yeast)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 4248 - 870 - 2011 21968018
    21 - 3909 - 870 - 2011 21968018
    21 - 4239 - 867 - 2011 21968018
    - splicing - - - - 2011 21968018
  • is associated with those signalling pathways that are inhibited by full length SULF1/SULF2 variants and therefore could promote growth in lung tumours
  • associate with activated EGF and HGF receptors leading to increases in the downstream signalling mediated through phosphoERK1/2 activity
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Hearing/EquilibriumearinnercochleaCortihighly Homo sapiens
    Reproductivefemale systembreastmammary gland highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivecartilage    Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • catalytic center residing in the N-terminal 75-kDa subunit
  • C-terminal 50-kDa subunit indispensable for both arylsufatase and glucosamine 6-O-sulfate-endosulfatase activity (Tang 2009)
  • HOMOLOGY
    intraspecies homolog to N-acetylglucosamine 6 sulfatase precursor
    Homologene
    FAMILY
  • sulfatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text secreted into conditioned medium, as well as retained on the cell membrane (Tang 2009)
    basic FUNCTION
  • exhibiting arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity
  • having the potential to modify the sulfation status of extracellular heparan sulfate proteoglycan (HSPG) glycosaminoglycan chains and thereby to regulate interactions with HSPG-binding proteins (Morimoto-Tomita 2005)
  • removes 6-O-sulfate groups on glucosamine from subregions of intact heparin (Uchimura 2006)
  • tool for deciphering the sulfation requirements in the interaction of protein ligands with heparin/HSPGs and expand the range of potential biological activities of this enzyme (Uchimura 2006)
  • extracellular sulfatase acting on internal glucosamine 6-O-sulfate modifications within heparan sulfate proteoglycans and regulating their interactions with various signaling molecules, including Wnt ligands (Tang 2009)
  • essential transcription factor for beta-type globin gene switching, that specifically activates transcription of the adult beta-globin gene promoter (Perrine 2009)
  • recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives (Perrine 2009)
  • extracellular sulfatases SULF1 and SULF2 remove specific 6-O-sulfate groups from heparan sulfate, thereby modulating numerous signalling pathways underlying development and homeostasis
  • regulates the activities of a number of signalling pathways that in many tissues are up-regulated during development and disease
  • promotes growth and metastasis of solid tumors
  • SULF1 and SULF2 differentially contribute to the generation of organ-specific sulfation patterns of heparan sulfate
  • overexpressed in idiopathic pulmonary fibrosis (IPF)and may play a role in regulating TGFB1 signaling in type II alveolar epithelial cells (AECs)
  • SULF1, SULF2 plays an important role in the development of the inner ear
  • SULF1, SULF2 and ERBB1 are likely involved in the signalling pathway from chondroitin sulphate proteoglycans (CSPGs)that leads to inhibition of neurite outgrowth and may regulate structural plasticity and regeneration in the nervous system
  • SULF1/SULF2 enzymes regulate cell signalling that impacts the growth and differentiation of many tissues
  • SULF1 and SULF2 play indispensable roles to maintain glomerular integrity and protective roles in diabetic nephropathy, probably by growth factor modulation
  • is a multifaceted protein involved in triglyceride-rich lipoprotein (TRL) homeostasis and angiogenesis
  • in addition to SULF1, SULF2 also plays an important and overlapping role in the motor neurons (MNs) to oligodendrocyte precursor cells (OPCs) fate change by regulating SHH signaling in the ventral spinal cord
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel positive regulator of neuroblastoma pathogenicity that contributes to MYCN oncogenicity
  • SULF2 facilitated lymphangiogenesis in breast cancer cells by regulating FIGF andvthe AKT1&
  • 8209;related signaling pathway was involved
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    proangiogenic heparan sulfate endosulfatase, upregulated in breast cancer (Morimoto-Tomita 2005)
    tumoral     --over  
    in most lung tumours showing differential cellular distribution of full length and shorter SULF2 variants in such tumours
    tumoral     --over  
    in pancreatic ductal adenocarcinoma was associated with advanced tumour stage, vascular invasion, shorter interval to radiological progression and shorter overall survival
    constitutional     --over  
    in cirrhotic liver compared to healthy liver
    constitutional     --over  
    in idiopathic pulmonary fibrosis (IPF)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • SULF2 methylation is a common abnormality and a prognostic biomarker for better survival of lung cancer patients
  • may be a useful serologic biomarker for liver cirrhosis
  • may have roles as a prognostic biomarker in pancreatic ductal adenocarcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    therapeutic target for patients with PDAC
    ANIMAL & CELL MODELS