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FLASH GENE

Symbol

SUGT1

contributors: mct - updated : 19-12-2012

HGNC name	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
HGNC id	16987

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	13q14.3      Physical location : 53.226.830 - 53.262.433
Synonym name	suppressor of G2 allele of SKP1, S. cerevisiae, homolog of
Synonym symbol(s)	SGT1

DNA

TYPE	functioning gene
STRUCTURE	35.60 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Physical map

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001130912 14 - 1801 NP_001124384 - 365 - - NM_006704 13 - 1705 NP_006695 - 333 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Endocrine pancreas       highly Respiratory lung         Skin/Tegument skin       highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Respiratory alveolar macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle, checkpoint, G1S, G2M

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal region containing a tetratricopeptide repeat (TPR)
	one central CS domain
	a C-terminal SGS domain (SGT1-specific)

HOMOLOGY

interspecies	ortholog to yeast S.cerevisiae Sgt1p
	homolog to murine Sugt1 (87.7pc)
	homolog to rattus Sugt1 (87.7pc)

Homologene

FAMILY

CATEGORY

adaptor , chaperone/stress , DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,chromatin/chromosome,kinetochore
text	dynamically localizes at the kinetochores, which lack microtubule attachments during prometaphase
	increase in intracellular concentration of Ca(2+), transduced by S100A6, is necessary for nuclear translocation of the SUGT1 protein

basic FUNCTION	centromere/kinetochore complex maturation
	involved in kinetochore function and required for the G1/S and G2/M transitions
	essential protein and critical assembly factor for the kinetochore
	activator of CTF13 protein
	may play a role in ubiquitination and subsequent proteosomal degradation of target proteins
	adaptor protein playing an essential role in signaling pathways linked to activation of NOD1 in epithelial lineage cells
	co-chaperone protein with an expression pattern matching that of the well known heat shock proteins

CELLULAR PROCESS	cell cycle, division, mitosis
	cell cycle, progression
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	associating with the SCF complex (SKP1/CDC53/F box protein) and ubiquitin ligase complex
	multiprotein complex with NOD1 that includes HSP90

INTERACTION

DNA

RNA

small molecule

protein	interacting with SKP1A/B
	positively regulates NOD1 activation
	ITG1BP2 interacts with SUGT1, an HSP90AA1 binding molecule
	increase in intracellular concentration of Ca(2+), transduced by S100A6, is necessary for nuclear translocation of the SUGT1 protein
	S100A6-SUGT1 dephosphorylation promotes its nuclear translocation, most likely due to disruption of the SUGT1-HSP90AA1 complex
	cochaperone for HSP90AA1, 1s a novel PLK1 substrate during mitosis

cell & other

REGULATION

Phosphorylated by

PLK1, that is required for the kinetochore localization of SUGT1 and phosphorylates serine 331 of SUGT1 at the kinetochores

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     might give rise to promote the transcription of the gene directly subsequent to the progression of colorectal cancer cases with worsening prognosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS