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FLASH GENE
Symbol SUGT1 contributors: mct - updated : 07-11-2017
HGNC name SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
HGNC id 16987
Location 13q14.3      Physical location : 53.226.830 - 53.262.433
Synonym name
  • suppressor of G2 allele of SKP1, S. cerevisiae, homolog of
  • putative 40-6-3 protein
  • Synonym symbol(s) SGT1
    DNA
    TYPE functioning gene
    STRUCTURE 48.07 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DDX26 13q14.12-q14.2 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 LOC220433 13q14.13 similar to ribosomal protein S4, X-linked WDFY2 13q14.12 WD repeat and FYVE domain containing 2 FLJ13639 13q14.2 hypothetical protein FLJ13639 FLJ37307 13q14.2 hypothetical protein FLJ37307 DKFZP434K1172 13q14.2 hypothetical protein DKFZp434K1172 LOC387926 13 hypothetical gene supported by AF338231; BC030655 ATP7B 13q14.3 ATPase, Cu++ transporting, beta polypeptide (Wilson disease) KIAA0266 13q12.2-q13.3 KIAA0266 protein LOC387927 13 similar to BB049667 protein MGC75495 13q14.2 similar to Serine/threonine-protein kinase Nek1 (NimA-related protein kinase 1) NEK3 13q14.2-q21.1 NIMA (never in mitosis gene a)-related kinase 3 LOC387928 13 similar to mitochondrial ribosomal protein S31; imogen 38 TPTEps1 13q14.2 TPTE and PTEN homologous inositol lipid phosphatase pseudogene THSD1 13q14.13 thrombospondin, type I, domain 1 C13orf9 13q14.13 chromosome 13 open reading frame 9 CKAP2 13q14 cytoskeleton associated protein 2 LOC387929 13 LOC387929 LOC220115 13q14.2 TPTE pseudogene LOC144983 13q14.2 hypothetical protein LOC144983 SUGT1 13q14.2 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) LECT1 13q14-q21 leukocyte cell derived chemotaxin 1 LOC121981 13q14.2 similar to peptidyl-Pro cis trans isomerase PCDH8 13q14.3 protocadherin 8 GW112 13q14.2 differentially expressed in hematopoietic lineages
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1801 - 365 - 2017 28696259
    13 - 1705 - 333 - 2017 28696259
    14 - 1879 - 277 - 2017 28696259
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinepancreas   highly
    Respiratorylung    
    Skin/Tegumentskin   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Respiratoryalveolar macrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, checkpoint, G1S, G2M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region containing a tetratricopeptide repeat (TPR)
  • one central CS domain
  • a C-terminal SGS domain (SGT1-specific)
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae Sgt1p
    homolog to murine Sugt1 (87.7pc)
    homolog to rattus Sugt1 (87.7pc)
    Homologene
    FAMILY
    CATEGORY adaptor , chaperone/stress , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • dynamically localizes at the kinetochores, which lack microtubule attachments during prometaphase
  • increase in intracellular concentration of Ca(2+), transduced by S100A6, is necessary for nuclear translocation of the SUGT1 protein
  • basic FUNCTION
  • centromere/kinetochore complex maturation
  • involved in kinetochore function and required for the G1/S and G2/M transitions
  • essential protein and critical assembly factor for the kinetochore
  • activator of CTF13 protein
  • may play a role in ubiquitination and subsequent proteosomal degradation of target proteins
  • adaptor protein playing an essential role in signaling pathways linked to activation of NOD1 in epithelial lineage cells
  • plays a role in various cellular processes including kinetochore assembly and protein ubiquitination by interacting with SKP1
  • SUGT1 could regulate AKT1 signaling pathway by modulating AKT1 ser473 phosphorylation status
  • co-chaperone protein with an expression pattern matching that of the well known heat shock proteins
  • possibility that SUGT1 competes with viral RNA for binding to EEF1A1
  • SUGT1 recruits HSP90AA1 chaperone activity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, progression
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • associating with the SCF complex (SKP1/CDC53/F box protein) and ubiquitin ligase complex
  • multiprotein complex with NOD1 that includes HSP90
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SKP1A/B
  • positively regulates NOD1 activation
  • ITG1BP2 interacts with SUGT1, an HSP90AA1 binding molecule
  • increase in intracellular concentration of Ca(2+), transduced by S100A6, is necessary for nuclear translocation of the SUGT1 protein
  • S100A6-SUGT1 dephosphorylation promotes its nuclear translocation, most likely due to disruption of the SUGT1-HSP90AA1 complex
  • cochaperone for HSP90AA1, 1s a novel PLK1 substrate during mitosis
  • SUGT1 interacts with SKP1, a small protein that heterodimerizes with proteins containing the F-box motif
  • PHLPP1 interacted with the essential outer-kinetochore protein SUGT1 and stabilized its protein levels
  • RNF41, an E3 ligase, ubiquitinated and degraded SUGT1 in a phosphorylation-dependent manner
  • SUGT1-HSP90AA1 complex contributes to the E3 ligase activity of the CUL4A complex that is necessary for CENPA ubiquitylation and CENPA deposition at the centromere
  • cell & other
    REGULATION
    Phosphorylated by PLK1, that is required for the kinetochore localization of SUGT1 and phosphorylates serine 331 of SUGT1 at the kinetochores
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    might give rise to promote the transcription of the gene directly subsequent to the progression of colorectal cancer cases with worsening prognosis
    tumoral     --over  
    in gastric cancer tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    could be a promising anti-cancer target to against gastric cancer
    ANIMAL & CELL MODELS