Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SUGT1 contributors: mct - updated : 19-12-2012
HGNC name SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
HGNC id 16987
Location 13q14.3      Physical location : 53.226.830 - 53.262.433
Synonym name suppressor of G2 allele of SKP1, S. cerevisiae, homolog of
Synonym symbol(s) SGT1
DNA
TYPE functioning gene
STRUCTURE 35.60 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
DDX26 13q14.12-q14.2 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 LOC220433 13q14.13 similar to ribosomal protein S4, X-linked WDFY2 13q14.12 WD repeat and FYVE domain containing 2 FLJ13639 13q14.2 hypothetical protein FLJ13639 FLJ37307 13q14.2 hypothetical protein FLJ37307 DKFZP434K1172 13q14.2 hypothetical protein DKFZp434K1172 LOC387926 13 hypothetical gene supported by AF338231; BC030655 ATP7B 13q14.3 ATPase, Cu++ transporting, beta polypeptide (Wilson disease) KIAA0266 13q12.2-q13.3 KIAA0266 protein LOC387927 13 similar to BB049667 protein MGC75495 13q14.2 similar to Serine/threonine-protein kinase Nek1 (NimA-related protein kinase 1) NEK3 13q14.2-q21.1 NIMA (never in mitosis gene a)-related kinase 3 LOC387928 13 similar to mitochondrial ribosomal protein S31; imogen 38 TPTEps1 13q14.2 TPTE and PTEN homologous inositol lipid phosphatase pseudogene THSD1 13q14.13 thrombospondin, type I, domain 1 C13orf9 13q14.13 chromosome 13 open reading frame 9 CKAP2 13q14 cytoskeleton associated protein 2 LOC387929 13 LOC387929 LOC220115 13q14.2 TPTE pseudogene LOC144983 13q14.2 hypothetical protein LOC144983 SUGT1 13q14.2 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) LECT1 13q14-q21 leukocyte cell derived chemotaxin 1 LOC121981 13q14.2 similar to peptidyl-Pro cis trans isomerase PCDH8 13q14.3 protocadherin 8 GW112 13q14.2 differentially expressed in hematopoietic lineages
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 1801 - 365 - -
13 - 1705 - 333 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrinepancreas   highly
Respiratorylung    
Skin/Tegumentskin   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
Respiratoryalveolar macrophage
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, checkpoint, G1S, G2M
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region containing a tetratricopeptide repeat (TPR)
  • one central CS domain
  • a C-terminal SGS domain (SGT1-specific)
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae Sgt1p
    homolog to murine Sugt1 (87.7pc)
    homolog to rattus Sugt1 (87.7pc)
    Homologene
    FAMILY
    CATEGORY adaptor , chaperone/stress , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • dynamically localizes at the kinetochores, which lack microtubule attachments during prometaphase
  • increase in intracellular concentration of Ca(2+), transduced by S100A6, is necessary for nuclear translocation of the SUGT1 protein
  • basic FUNCTION
  • centromere/kinetochore complex maturation
  • involved in kinetochore function and required for the G1/S and G2/M transitions
  • essential protein and critical assembly factor for the kinetochore
  • activator of CTF13 protein
  • may play a role in ubiquitination and subsequent proteosomal degradation of target proteins
  • adaptor protein playing an essential role in signaling pathways linked to activation of NOD1 in epithelial lineage cells
  • co-chaperone protein with an expression pattern matching that of the well known heat shock proteins
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, progression
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • associating with the SCF complex (SKP1/CDC53/F box protein) and ubiquitin ligase complex
  • multiprotein complex with NOD1 that includes HSP90
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SKP1A/B
  • positively regulates NOD1 activation
  • ITG1BP2 interacts with SUGT1, an HSP90AA1 binding molecule
  • increase in intracellular concentration of Ca(2+), transduced by S100A6, is necessary for nuclear translocation of the SUGT1 protein
  • S100A6-SUGT1 dephosphorylation promotes its nuclear translocation, most likely due to disruption of the SUGT1-HSP90AA1 complex
  • cochaperone for HSP90AA1, 1s a novel PLK1 substrate during mitosis
  • cell & other
    REGULATION
    Phosphorylated by PLK1, that is required for the kinetochore localization of SUGT1 and phosphorylates serine 331 of SUGT1 at the kinetochores
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    might give rise to promote the transcription of the gene directly subsequent to the progression of colorectal cancer cases with worsening prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS