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FLASH GENE
Symbol SUCNR1 contributors: mct/npt - updated : 14/11/2008
HGNC name succinate receptor 1
HGNC id 4542
Location 3q25.1      Physical location : 151.591.430 - 151.599.876
Synonym name
  • G protein-coupled receptor 91
  • P2Y purinoceptor 1
  • P2Y purinoceptor 1-like
  • Synonym symbol(s) GPR91
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 8.21 kb     3 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1448 - 334 - Macaulay (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunespleen    
    Reproductivefemale systemplacenta   
    Urinarykidney    
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualganglion cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • in response to increased succinate levels, regulate the production of numerous angiogenic factors including VEGF
  • may be involved in the modulation of platelet function
  • playing a role in proliferative ischemic retinopathy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text receptor for the citric acid cycle intermediate succinate
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • function for succinate and its receptor SUCNR1 in establishing a neovascular network during development and in response to injury
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • attractive target for treating diseases such as diabetic retinopathy that stem from aberrant neovascularization in the mature retina
  • alternative target to govern revascularization after ischemia
  • ANIMAL & CELL MODELS