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FLASH GENE
Symbol SUCLG2 contributors: mct/npt - updated : 03-11-2015
HGNC name succinate-CoA ligase, GDP-forming, beta subunit
HGNC id 11450
Location 3p14.1      Physical location : 67.410.884 - 67.705.038
Synonym name
  • succinyl-CoA ligase, GDP-forming, beta chain, mitochondrial precursor
  • succinyl-CoA synthetase, beta-G chain
  • GTP-specific succinyl-CoA synthetase beta subunit
  • Synonym symbol(s) G-BETA, SCB2, SCS-betaG
    EC.number 6.2.1.4
    DNA
    TYPE functioning gene
    STRUCTURE 294.15 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HT021 3p21.1 HT021 FEZL 3p21.1 likely ortholog of mouse and zebrafish forebrain embryonic zinc finger-like CADPS 3p21.1-p14.3 Ca2+-dependent activator protein for secretion LOC389127 3 similar to 40S ribosomal protein S10 LOC132205 3p21.1 similar to keratin 8, type II cytoskeletal - human SYNPR 3p14.3 synaptoporin LOC132203 3p21.1 similar to hypothetical protein A430083B19 LOC391542 3 similar to hypothetical protein FLJ23834 LOC132200 3p21.1 hypothetical protein BC015210 NIF3L1BP1 3p21.1 Ngg1 interacting factor 3 like 1 binding protein 1 SCA7 3p13-p12 spinocerebellar ataxia 7 (olivopontocerebellar atrophy with retinal degeneration) p44S10 3p21.1 proteasome regulatory particle subunit p44S10 PRICKLE2 3p21.1 prickle-like 2 (Drosophila) ADAMTS9 3p14.3-p14.2 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9 BAIAP1 3p14.1 BAI1-associated protein 1 SLC25A26 3p14.3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 26 LRIG1 3p14 leucine-rich repeats and immunoglobulin-like domains 1 TA-KRP 3p14 T-cell activation kelch repeat protein SUCLG2 3p14.3 succinate-CoA ligase, GDP-forming, beta subunit LOC375350 3p14.3 COP9 pseudogene LOC151645 3p14.3 protease (prosome, macropain) 26S subunit, ATPase, 1 pseudogene FLJ25161 3p14.3-p14.2 hypothetical protein FLJ25161 LOC152122 3p14.2 hypothetical LOC152122 MGC34132 3p14.2 hypothetical protein MGC34132 TMF1 3p21-p12 TATA element modulatory factor 1 UBE1C 3p24.3-p13 ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) JWA 3p14 ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) LMOD3 3p14.1 leiomodin 3 (fetal) GRSP1 3p14.2 leiomodin 3 (fetal) MITF 3p14.1-p12.3 microphthalmia-associated transcription factor LOC391543 3 similar to KIAA1839 protein FOXP1 3p14.1 forkhead box P1 LOC391544 3 similar to MGC39820 protein GPR27 3p21-p14 G protein-coupled receptor 27 PROK2 3p21.1 prokineticin 2 RYBP 3p13 RING1 and YY1 binding protein LOC339875 3p14.2 hypothetical LOC339875 FLJ10539 3p14.2 hypothetical protein FLJ10539 LOC317753 3p14 proteasome 26S non-ATPase subunit 12 pseudogene LOC389129 3 similar to CG9996-PA PPP4R2 3q28 protein phosphatase 4, regulatory subunit 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2369 - 432 - 2004 15234968
    11 - 1520 - 440 - 2004 15234968
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiens
    Nervousbrainhindbrainmedulla oblongata   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • succinate/malate CoA ligase beta subunit family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text
  • exist only in cells forming the vasculature or its contents in the human brain
  • basic FUNCTION
  • catalyze the reverse reaction in the citric acid cycle in which the ADP-forming enzyme augments ATP production, whereas the GDP-forming enzyme supports GTP-dependent anabolic processes (Lambeth 204)
  • SUCLG2, to a higher degree than SUCLA2, is crucial for mtDNA maintenance and mitochondrial NME1 is involved
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS