Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

SUCLG1

contributors: mct - updated : 23-03-2011

HGNC name	succinate-CoA ligase, GDP-forming, alpha subunit
HGNC id	11449

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	FLAMM fatal lactic acidosis with methylmalonic aciduria
Location	2p11.2      Physical location : 84.650.646 - 84.686.586
Synonym symbol(s)	SUCLA1, SUCA, FLJ21114
EC.number	6.2.1.4

DNA

TYPE	functioning gene
STRUCTURE	35.94 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003849 9 - 1475 - 346 - 2004 15234968

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Hearing/Equilibrium ear inner cochlea   highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	CoA binding domain
	mitochondrial targeting sequence (27AA)

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Suclg1

Homologene

FAMILY

succinate/malate CoA ligase alpha subunit family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION

involved in the tricarboxylic acid cycle

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

fatty acid

a component

an alpha and a beta chain

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

thyroid hormones

ASSOCIATED DISORDERS

corresponding disease(s)

FLAMM

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS