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FLASH GENE
Symbol STYXL1 contributors: mct - updated : 04-10-2011
HGNC name serine/threonine/tyrosine interacting-like 1
HGNC id 18165
Location 7q11.23      Physical location : 75.625.655 - 75.677.321
Synonym name
  • map kinase phosphatase-like protein
  • MAPK (mitogen-activated protein kinase) phospho-serine/threonine/tyrosine-binding protein
  • dual specificity phosphatase inhibitor MK-STYX
  • dual specificity phosphatase 24
  • dual specificity phosphatase 24 (putative)
  • Synonym symbol(s) MK-STYX, DUSP24
    DNA
    TYPE functioning gene
    STRUCTURE 51.67 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 1429 53 313 - 1998 9757831
    - splicing - 28 247 - Dayton
    - splicing - 36 318 - Dayton
    - splicing - 24 217 - Walker
    - splicing - 12 111 - Walker
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     pancreas exocrine   moderately
    Nervousbrain   moderately
    Reproductivefemale systemovary  predominantly
    Respiratorylung   moderately
     respiratory tractlarynx  moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a rhodanese domain
  • a tyrosine-protein phosphatase domain
  • a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase
  • a binding pocket for phosphorylated substrates
  • HOMOLOGY
    interspecies ortholog to murine Dusp24
    Homologene
    FAMILY
  • dual-specificity phosphatase subfamily of the PTPs (protein tyrosine phosphatases)
  • non-receptor class subfamily
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • localize to the mitochondria but is neither released from the mitochondria upon apoptotic stress nor proximal to the machinery currently known to control mitochondrial outer membrane permeabilization
  • basic FUNCTION
  • probable pseudophosphatase
  • acting as a protein tyrosine/serine/threonine phosphatase
  • having a role for MK-STYX in regulating the ability of G3BP1 to integrate changes in growth-factor stimulation and environmental stress with the regulation of protein synthesis
  • catalytically inactive phosphatase with homology to the mitogen-activated protein kinase (MAPK) phosphatases
  • regulates mitochondrial outer membrane permeabilization using a distinct mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • intracellular signaling cascade
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein G3BP1 a regulator of Ras signalling, is a binding partner of STYXL1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS