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FLASH GENE
Symbol STYX contributors: mct - updated : 19-04-2022
HGNC name serine/threonine/tyrosine interacting protein
HGNC id 11447
Location 14q22.1      Physical location : 53.196.882 - 53.241.703
Synonym name
  • protein tyrosine phosphatase-like protein
  • Synonym symbol(s) FLJ42934
    DNA
    TYPE functioning gene
    STRUCTURE 44.82 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text an alternatively spliced form of STYX containing a unique carboxyl terminus (Wishart)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 4864 - 223 - 2017 28408485
    12 - 4616 - 223 - 2017 28408485
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   moderately
     stomach   highly
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemtestis  moderately
     male systemprostate  moderately
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscular    
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a tyrosine-protein phosphatase domain
  • containing a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase
  • a binding pocket for phosphorylated substrates
  • HOMOLOGY
    interspecies ortholog to murine Styx
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class subfamily
  • dual-specificity phosphatases (DUSPs) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • STYX localizes to the nucleus
  • basic FUNCTION
  • probable pseudophosphatase
  • seems to play a role in spermiogenesis
  • STYX is an important regulator of ERK1/2 signaling critical for cell migration and PC12 cell differentiation
  • STYX and MAPK-STYX (STYXL1), are integral signaling molecules in regulating pathways involved in neuronal developmental processes such as neurite outgrowth
  • STYX acts as a nuclear anchor for MAPKs, affecting their nucleo-cytoplasmic shuttling
  • STYX plays an oncogenic role by inhibiting FBXW7
  • very specific role of STYX and STYXL1 for each pseudophosphatase, further highlighting the relevance of these atypical members of DUSP as signaling regulators
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    text spermiogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CARHSP1/Crhsp-24
  • STYX is a spatial regulator of ERK signaling
  • STYX bound to FBXW7 protein and inhibited its function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • prognostic biomarker in colorectal cancer (CRC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    potential therapeutic target in colorectal cancer (CRC)
    ANIMAL & CELL MODELS