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FLASH GENE
Symbol STXBP3 contributors: mct/pgu - updated : 23-09-2011
HGNC name syntaxin binding protein 3
HGNC id 11446
Location 1p13.3      Physical location : 109.289.284 - 109.352.139
Synonym name
  • syntaxin-binding protein 4
  • Synonym symbol(s) UNC18C,UNC18-3, PSP, MUNC18C, UNC-18C, MUNC18-3
    DNA
    TYPE functioning gene
    STRUCTURE 62.86 kb     19 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 2522 67 592 - 1996 8824310
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Digestivepharynx   moderately
     salivary gland   moderately
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunethymus   moderately
    Respiratoryrespiratory tracttrachea  moderately
    Urinarybladder   highly
     kidney   moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Stxbp3 (90.7 pc)
    homolog to murine Stxbp3a (91.5 pc)
    Homologene
    FAMILY
  • S/M (sec1/munc18) protein family
  • STXBP/unc-18/sec1 family
  • CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text found on the plasma membrane
    basic FUNCTION
  • involved in intracellular vesicular transport
  • regulating vesicle docking
  • may preferentially regulate the fusion of secondary granules
  • essential positive role in second-phase glucose-stimulated insulin secretion, suggesting novel roles for STXBP3 in granule localization to the plasma membrane as well as in triggering STX4 accessibility to VAMP2 at a step preceding vesicle docking/fusion
  • plays a separate role in the polarized localization of STX4
  • stabilizes syntaxin 4 at the plasma membrane
  • is required only for second phase insulin release
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • protein transport
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with STX4A (inhibited by phosphorylation)
  • interacting with STX4 (STXBP3 binding is required for stabilization of syntaxin 4 at the plasma membrane but not for its correct targeting)
  • IR is the first known tyrosine kinase for STXBP3 as part of a new insulin-signaling step in SLC2A4 vesicle exocytosis
  • SNARE-interacting protein (is a potential regulator of SNAP23)
  • cell & other
    REGULATION
    Other phosphorylated by PKC in platelets in response to thrombin stimulation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS