basic FUNCTION
| soluble N ethylmaleimide-sensitive factor-attachment protein receptor, SNARE protein, involved in neurotransmission |
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regulates synaptic vesicle release, at least in part, by binding to syntaxin 1A (STX1A) as well as to the SNARE complex directly |
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expressed in an estrogen-dependent manner, plays an important role in the onset of female puberty via the regulation of glutamate release |
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participating in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins |
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involved in the regulation of SNARE complex-dependent membrane fusion events implicated in the ramification of axonal processes in neurons |
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may play a role in determining the specificity of intracellular fusion reactions |
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controling multiple stages of exocytosis via both syntaxin-dependent and -independent protein interactions |
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plays a positive role in regulated insulin secretion from pancreatic beta cells |
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has a chaperone function in neurons, promoting anterograde transport of the plasma membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein Syntaxin-1 |
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acts as a molecular chaperone for Syntaxin transport in neurons and the two modes of STXBP1 binding to Syntaxin are involved in different aspects of STXBP1 function |
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controls the accessibility of STX1A to its partners, a role that might be common to all SM proteins (Sec1/Munc18-like) |
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participates in the establishment of the membrane fusion pore, a step that is thought to occur after complete zipping of the SNARE complex |
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UNC13A, STXBP1 regulate early neurite outgrowth |
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acting at specific steps of intracellular membrane transport |
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required for the first phase of insulin secretion |
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indirectly promotes STX4-based granule docking and exocytosis to support the first phase of insulin secretion |
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key role for STXBP1 in first-phase exocytotic processes relevant to the maintenance of whole-body glucose homeostasis |
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has an essential role in acrosomal exocytosis |
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plays a key role in the dynamics of trans-SNARE complex assembly and/or stabilization, a process that is necessary for the docking of the outer acrosomal membrane to the plasma membrane and subsequent fusion pore opening |
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STXBP1 plays a dual role in transporting syntaxin-1A (STX1A) to the plasma membrane and regulating SNARE-mediated membrane fusion |
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promotes the zippering of trans-SNARE complexes and accelerates the kinetics of SNARE-dependent membrane fusion |
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cell death upon STXBP1, STX1A, or SNAP25 loss occurs via a degenerative pathway unrelated to the known synapse function of these proteins and involving early cis-Golgi abnormalities, distinct from apoptosis |