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FLASH GENE
Symbol STX6 contributors: mct/npt - updated : 13-04-2018
HGNC name syntaxin 6
HGNC id 11441
Location 1q25.3      Physical location : 180.942.178 - 180.992.046
DNA
TYPE functioning gene
STRUCTURE 50.41 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 4548 - 255 - 2016 2690662
6 - 4809 - 154 - 2016 2690662
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea highly
Lymphoid/Immunethymus   highly
Respiratoryrespiratory tractlarynx  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil
Lymphoid/Immunelymphocyte
cell lineage
cell lines neutrophil-differentiated Hl-60, SH-SYSY neuroblastoma cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a T-SNARE coiled-coil homology domain, and the first coiled-coil domain plays a crucial role in NGF-dependent neurite outgrowth
  • HOMOLOGY
    Homologene
    FAMILY
  • syntaxin family
  • CATEGORY receptor membrane , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm
    text
  • granule membranes, perinuclear region
  • expressed in trans-Golgi and endosomes
  • basic FUNCTION
  • SNAP receptor (SNARE), involved in intracellular vesicle trafficking
  • vesicle transporter protein, directly regulated by each of the TP53 family proteins
  • effector and a modulator of the TP53 family in the regulation of cell adhesion and survival
  • both VTI1B and STX6 function and have rate-limiting roles in TNFalpha trafficking and secretion
  • regulate the caveolae- but not clathrin-dependent endocytosis
  • regulates trans-Golgi network trafficking and the secretory pathway via its coiled-coil domains
  • involved in multiple secretory and endocytic pathways, such as endosomal maturation
  • importance of STX6 in the maintenance of cellular KDR levels, suggesting that the inhibitory form of STX6 has good potential as an antiangiogenic agent
  • regulation of intracellular membrane trafficking and cell dynamics by STX6
  • plays a rate-limiting role in cell migration and integrin trafficking
  • is involved in diverse cellular functions in a variety of cell types and has been shown to regulate many intracellular membrane trafficking events such as endocytosis, recycling and anterograde and retrograde trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
  • potential new integrin trafficking pathway in which endocytosed integrins are transported from VAMP3-containing recycling endosomes to STX6-containing trans-Golgi network before being recycled to the plasma membrane
  • a component
  • component of vesicle trafficking apparatus
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SNA23A, SNAP23B
  • binding to GOPC
  • binds EEA1 and MARCH2
  • associated with a variety of SNARE proteins
  • interacts with VPS45
  • target gene of the TP53 Family
  • recycling of LNPEP from the plasma membrane back to the insulin-responsive compartment requires the Q-SNARE STX6 but not the GGA clathrin adaptors
  • involvement of a GOPC-binding SNARE protein STX6 in the degradation of CFTR, but STX6 does not bind to ER-localized DeltaF508-CFTR
  • COG interacts directly with the target membrane SNARE (t-SNARE) STX6 via the COG6 subunit
  • ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins GOPC and STX6
  • elevated ANXA6 levels cause late endosome (LE) cholesterol accumulation, ANXA6 and blockage of LE cholesterol transport are critical for endosomal function required for STX6-mediated recycling of integrins in cell migration
  • cell & other
    REGULATION
    Other cholesterol regulates STX6 trafficking at trans-Golgi network endosomal boundaries
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    respiratoryCF (mucoviscidosis) 
    possible therapeutic role of STX6 in enhancing rescued DeltaF508-CFTR
    cancerdigestiveoesophagus
    might be a valuable target for ESCC therapy
    ANIMAL & CELL MODELS