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FLASH GENE
Symbol STX5 contributors: mct/npt - updated : 01-03-2014
HGNC name syntaxin 5
HGNC id 11440
Location 11q12.3      Physical location : 62.574.369 - 62.599.560
Synonym name syntaxin 5A
Synonym symbol(s) STX5A, SED5
DNA
TYPE functioning gene
STRUCTURE 25.23 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1834 39 355 - 2008 18836075
11 - 1872 - 321 - 2008 18836075
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Stx5a
Homologene
FAMILY
  • syntaxin family
  • SNARE proteins family
  • CATEGORY receptor , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • regulation of protein transport by binding to VAMP (vesicle-associated membrane protein)
  • required for an endogenous cargo protein - the mannose 6-phosphate receptor - and for the productive trafficking into cells of cholera toxin and ricin
  • also has trafficking-independent functions
  • essential role for the syntaxin-5 SNARE complex in autophagy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • STX5 SNARE complex regulates the later stages of autophagy after the initial formation of autophagosomes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VAMP
  • putative interacting partner of PKD2 (functioning to inactivate PKD2 and preventing leaking of Ca2+ from ER stores)
  • GOLGA2 binding to STX5 is specific, direct, and mediated by the membrane-proximal region of GOLGA2
  • interactions of GOLGA2 with STX5 and RAB1A are also regulated by mitotic phosphorylation, which is likely to contribute to the inhibition of ER to Golgi trafficking that occurs when mammalian cells enter mitosis
  • COG4-STX5 interactions (COG4 protein initiate the formation of two different tethering platforms that can facilitate the redirection of two populations of Golgi transport intermediates to the mitochondrial vicinity)
  • STX5 might play a role in modulating VLDLR physiology by participating in an abrasively described or completely novel Golgi-bypass pathway
  • STX5 is monoubiquitinated by the ubiquitin ligase HACE1 in early mitosis and deubiquitinated by the deubiquitinase VCPIP1 in late mitosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum anti-STX5 autoantibody, which was discovered by a proteomic approach, is a potential new serum marker for the diagnosis of endometriosis
  • Therapy target
    ANIMAL & CELL MODELS