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FLASH GENE
Symbol STX18 contributors: mct/npt - updated : 28-09-2009
HGNC name syntaxin 18
HGNC id 15942
Location 4p16.2      Physical location : 4.420.697 - 4.543.775
Synonym name
  • target-SNAP-soluble NSF (N-ethylmaleimide-sensitive factor)
  • cell growth-inhibiting gene 9 protein
  • Synonym symbol(s) Ufe1, DKFZp686O15149, Qa-SNARE
    DNA
    TYPE functioning gene
    STRUCTURE 123.08 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2162 38.6 335 - Hatsuzawa (2000)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • syntaxin family
  • CATEGORY receptor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • target-soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE)
  • plays a role in the growth of breast cancer cells (Bassett 2008)
  • SNAP (soluble NSF attachment protein) receptor localized in the ER, is important for the organization of two ER subdomains, smooth/rough ER membranes and ER exit sites (Iinuma 2009)
  • has an important role in ER subdomain organization by mediating the fusion of retrograde membrane carriers with the ER membrane (Iinuma 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text transport between RE and Golgi
    PATHWAY
    metabolism
    signaling
    a component
  • ER (endoplasmic reticulum)-localized syntaxin 18 (Qa-SNARE) forms a complex with BNIP1 (Qb-SNARE), USE1(Qc-SNARE), SEC22B (R-SNARE) and several peripheral membrane proteins (Aoki 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • association with SEC22B induces an increase in alpha-. helicity of their SNARE motifs, which results in the formation of high-affinity binding sites for BNIP1 and USE1 (Aoki 2008)
  • physically interact with proteins involved in the cell cycle and apoptosis (Bassett 2008)
  • BNIP1 functions as a component of the STX18 SNARE complex and regulates retrograde transport from the Golgi to the endoplasmic reticulum
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer (Bassett 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS