Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol STX17 contributors: mct - updated : 20-08-2015
HGNC name syntaxin 17
HGNC id 11432
Location 9q31.1      Physical location : 102.668.914 - 102.736.817
Synonym symbol(s) FLJ20651
DNA
TYPE functioning gene
STRUCTURE 72.70 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
TBC1D2 9q22.33 TBC1 domain family, member 2 GPR51 9q22.1 G protein-coupled receptor 51 SAMD6 9q31.1 sterile alpha motif domain containing 6 GALNT12 9q22.33 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12) LOC392372 9 similar to Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (P18) COL15A1 9q22.32-q22.33 collagen, type XV, alpha 1 TGFBR1 9q22 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) ALG2 9q31.1 asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase) SEC61B 9q22.32-q31.3 asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase) LOC347265 9q31.1 similar to bA13B9.3 (novel protein similar to KRT8) LOC389778 9 LOC389778 NR4A3 9q22.32-q22.33 nuclear receptor subfamily 4, group A, member 3 STX17 9q31.1 syntaxin 17 INVS 9q31 inversin FLJ20287 9q31.1 hypothetical protein FLJ20287 MGC17337 9q31.1 similar to RIKEN cDNA 5730528L13 gene TMEFF1 9q31 transmembrane protein with EGF-like and two follistatin-like domains 1 LOC347273 9q31.1 similar to RIKEN cDNA 2310039E09 LOC392373 9 similar to ACTB protein LOC392374 9 similar to uracil DNA glycosylase FLJ20300 LOC347275 9q31.1 similar to RIKEN cDNA C730036D15 BAAT 9q22.3 bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) MRPL50 9q31.1 mitochondrial ribosomal protein L50 ZNF189 9q22-q31 zinc finger protein 189 ALDOB 9q21.3-q22.2 aldolase B, fructose-bisphosphate MGC12992 9q31.1 hypothetical protein MGC12992 RNF20 9q22 ring finger protein 20
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 6910 - 302 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Reproductivemale systemtestis  highly
Skin/Tegumentskin appendageshairfollicle   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one t-SNARE coiled coil homology domain
  • two transmembrane domains, each containing glycine zipper motifs
  • tyrosine-based motif which is required for its incorporation into COPII (coatomer protein II) vesicles, exit from the ER and localization to the ERGIC
  • a unique C-terminal hairpin structure mediated by two tandem transmembrane domains containing glycine zipper-like motifs, which is essential for its association with the autophagosomal membrane
  • HOMOLOGY
    interspecies homolog to murine 9030425C21Rik
    homolog to rattus LOC252853
    intraspecies homolog to syntaxin 13, syntaxin 7
    Homologene
    FAMILY syntaxin/epimorphin family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • type IV membrane protein
  • localizes to the outer membrane of completed autophagosomes but not to the isolation membrane (unclosed intermediate structures); for this reason, the lysosome does not fuse with the isolation membrane (pMID: 23217709)
  • present on raft-like structures of ER-mitochondria contact sites and promotes mitochondrial fission by determining DNM1L localization and activity
  • basic FUNCTION
  • involved in vesicular trafficking to lysosomes
  • is essential for maintaining the architecture of ERGIC and Golgi
  • autophagosomal SNARE required for fusion with the endosome/lysosome
  • has a hairpin-type structure mediated by two transmembrane domains, each containing glycine zipper motifs, contributing to its specific localization to completed autophagosomes but not to phagophores
  • late recruitment of STX17 to completed autophagosomes could prevent premature fusion of the lysosome with unclosed phagophores
  • might contribute to proper phagophore assembly
  • acts as a switch that responds to nutrient conditions and integrates functions for the ER and autophagosomes with mitochondrial dynamics
  • upon autophagy induction STX17 is strictly required for ATG14 recruitment to the ER-mitochondria contact sites, a critical step for the assembly of the phagophore and therefore for autophagosome formation
  • plays a role in the early events of autophagy by interacting with the phosphatidylinositol 3-kinase complex component ATG14
  • STX17, SNAP29, and VAMP8, are potentially essential for the fusion between autophagosomes and lysosomes
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with syntaxin 3
  • ER-resident SNARE protein syntaxin 17 (STX17) binds ATG14 and recruits it to the ER-mitochondria contact site
  • interacts with SNAP29 and the lysosomal SNARE VAMP8, and all of these proteins are required for autophagosome-lysosome fusion
  • HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17
  • promotes mitochondrial fission by determining DNM1L localization and activity
  • ATG14 binds to the SNARE core domain of STX17 through its coiled-coil domain, and stabilizes the STX17-SNAP29 binary t-SNARE complex on autophagosomes
  • ATG14-STX17-SNAP29 interaction mediates autophagosome-lysosome tethering and fusion events, thus revealing a novel function of ATG14 in the later steps of the autophagy pathway
  • ATG14 directly binds to the STX17-SNAP29 binary complex on autophagosomes and promotes STX17-SNAP29-VAMP8-mediated autophagosome fusion with lysosomes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS